Cargando…

The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction

BACKGROUND: Despite efforts to prevent postoperative discomfort, there are still many immediate side effects associated with the surgical extraction of impacted lower third molars. Cicatrization is a physiological process through which the loss of integrity of oral mucosa is recovered and damaged ti...

Descripción completa

Detalles Bibliográficos
Autores principales: Madrazo-Jiménez, Marta, Rodríguez-Caballero, Ángela, Serrera-Figallo, María-Ángeles, Garrido-Serrano, Roberto, Gutiérrez-Corrales, Aida, Gutiérrez-Pérez, José-Luis, Torres-Lagares, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116111/
https://www.ncbi.nlm.nih.gov/pubmed/27475700
http://dx.doi.org/10.4317/medoral.21281
_version_ 1782468615250903040
author Madrazo-Jiménez, Marta
Rodríguez-Caballero, Ángela
Serrera-Figallo, María-Ángeles
Garrido-Serrano, Roberto
Gutiérrez-Corrales, Aida
Gutiérrez-Pérez, José-Luis
Torres-Lagares, Daniel
author_facet Madrazo-Jiménez, Marta
Rodríguez-Caballero, Ángela
Serrera-Figallo, María-Ángeles
Garrido-Serrano, Roberto
Gutiérrez-Corrales, Aida
Gutiérrez-Pérez, José-Luis
Torres-Lagares, Daniel
author_sort Madrazo-Jiménez, Marta
collection PubMed
description BACKGROUND: Despite efforts to prevent postoperative discomfort, there are still many immediate side effects associated with the surgical extraction of impacted lower third molars. Cicatrization is a physiological process through which the loss of integrity of oral mucosa is recovered and damaged tissues are repaired. Bexident Post (ISDIN, Spain) is a topical gel that contains chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol. While this gel has many clinical indications, there are no published clinical trials evaluating its use in impacted mandibular third molar surgery. This study aims to clinically evaluate the efficacy of a gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol on wound healing and reduction of postoperative side effects and complications after extraction of an impacted mandibular third molar. MATERIAL AND METHODS: A split-mouth design study was carried out on a total of 50 bilaterally and symmetrically impacted third molar extractions, which were randomly placed into either a control group (CG=25) or an experimental group (EG=25). Patients were all informed of the purpose of the study and provided written consent. All procedures were carried out by the same dental practitioner, in accordance with standard surgical protocol. A different dental practitioner, unaware of which treatment had been applied, provided follow-up care. The EG applied 10 ml of topical gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol to the surgical wound three times a day for 10 days, patients in the CG did not apply any gel. RESULTS: The groups were homogeneous insofar as potentially confounding variables. No significant findings were found regarding postoperative swelling and pain. Neither of the groups displayed poor healing or infectious complications of the wound during the postoperative period. In all the recorded follow-ups (Day 7 p=0.001, and Day 14 p=0.01), the wound’s aesthetic appearance was better in the EG. Overall treatment tolerance was satisfactory and similar in both groups. CONCLUSIONS: The gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not aid in patients’ postoperative comfort; however, improved wound healing was observed. Key words:Impacted lower third molar, postoperative wound healing, chitosan, chlorhexidine, allantoin, dexpanthenol, postoperative period.
format Online
Article
Text
id pubmed-5116111
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Medicina Oral S.L.
record_format MEDLINE/PubMed
spelling pubmed-51161112016-11-29 The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction Madrazo-Jiménez, Marta Rodríguez-Caballero, Ángela Serrera-Figallo, María-Ángeles Garrido-Serrano, Roberto Gutiérrez-Corrales, Aida Gutiérrez-Pérez, José-Luis Torres-Lagares, Daniel Med Oral Patol Oral Cir Bucal Research BACKGROUND: Despite efforts to prevent postoperative discomfort, there are still many immediate side effects associated with the surgical extraction of impacted lower third molars. Cicatrization is a physiological process through which the loss of integrity of oral mucosa is recovered and damaged tissues are repaired. Bexident Post (ISDIN, Spain) is a topical gel that contains chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol. While this gel has many clinical indications, there are no published clinical trials evaluating its use in impacted mandibular third molar surgery. This study aims to clinically evaluate the efficacy of a gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol on wound healing and reduction of postoperative side effects and complications after extraction of an impacted mandibular third molar. MATERIAL AND METHODS: A split-mouth design study was carried out on a total of 50 bilaterally and symmetrically impacted third molar extractions, which were randomly placed into either a control group (CG=25) or an experimental group (EG=25). Patients were all informed of the purpose of the study and provided written consent. All procedures were carried out by the same dental practitioner, in accordance with standard surgical protocol. A different dental practitioner, unaware of which treatment had been applied, provided follow-up care. The EG applied 10 ml of topical gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol to the surgical wound three times a day for 10 days, patients in the CG did not apply any gel. RESULTS: The groups were homogeneous insofar as potentially confounding variables. No significant findings were found regarding postoperative swelling and pain. Neither of the groups displayed poor healing or infectious complications of the wound during the postoperative period. In all the recorded follow-ups (Day 7 p=0.001, and Day 14 p=0.01), the wound’s aesthetic appearance was better in the EG. Overall treatment tolerance was satisfactory and similar in both groups. CONCLUSIONS: The gel composed of chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not aid in patients’ postoperative comfort; however, improved wound healing was observed. Key words:Impacted lower third molar, postoperative wound healing, chitosan, chlorhexidine, allantoin, dexpanthenol, postoperative period. Medicina Oral S.L. 2016-11 2016-07-31 /pmc/articles/PMC5116111/ /pubmed/27475700 http://dx.doi.org/10.4317/medoral.21281 Text en Copyright: © 2016 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Madrazo-Jiménez, Marta
Rodríguez-Caballero, Ángela
Serrera-Figallo, María-Ángeles
Garrido-Serrano, Roberto
Gutiérrez-Corrales, Aida
Gutiérrez-Pérez, José-Luis
Torres-Lagares, Daniel
The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction
title The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction
title_full The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction
title_fullStr The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction
title_full_unstemmed The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction
title_short The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction
title_sort effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116111/
https://www.ncbi.nlm.nih.gov/pubmed/27475700
http://dx.doi.org/10.4317/medoral.21281
work_keys_str_mv AT madrazojimenezmarta theeffectsofatopicalgelcontainingchitosan02chlorhexidineallantoinanddespanthenolonthewoundhealingprocesssubsequenttoimpactedlowerthirdmolarextraction
AT rodriguezcaballeroangela theeffectsofatopicalgelcontainingchitosan02chlorhexidineallantoinanddespanthenolonthewoundhealingprocesssubsequenttoimpactedlowerthirdmolarextraction
AT serrerafigallomariaangeles theeffectsofatopicalgelcontainingchitosan02chlorhexidineallantoinanddespanthenolonthewoundhealingprocesssubsequenttoimpactedlowerthirdmolarextraction
AT garridoserranoroberto theeffectsofatopicalgelcontainingchitosan02chlorhexidineallantoinanddespanthenolonthewoundhealingprocesssubsequenttoimpactedlowerthirdmolarextraction
AT gutierrezcorralesaida theeffectsofatopicalgelcontainingchitosan02chlorhexidineallantoinanddespanthenolonthewoundhealingprocesssubsequenttoimpactedlowerthirdmolarextraction
AT gutierrezperezjoseluis theeffectsofatopicalgelcontainingchitosan02chlorhexidineallantoinanddespanthenolonthewoundhealingprocesssubsequenttoimpactedlowerthirdmolarextraction
AT torreslagaresdaniel theeffectsofatopicalgelcontainingchitosan02chlorhexidineallantoinanddespanthenolonthewoundhealingprocesssubsequenttoimpactedlowerthirdmolarextraction
AT madrazojimenezmarta effectsofatopicalgelcontainingchitosan02chlorhexidineallantoinanddespanthenolonthewoundhealingprocesssubsequenttoimpactedlowerthirdmolarextraction
AT rodriguezcaballeroangela effectsofatopicalgelcontainingchitosan02chlorhexidineallantoinanddespanthenolonthewoundhealingprocesssubsequenttoimpactedlowerthirdmolarextraction
AT serrerafigallomariaangeles effectsofatopicalgelcontainingchitosan02chlorhexidineallantoinanddespanthenolonthewoundhealingprocesssubsequenttoimpactedlowerthirdmolarextraction
AT garridoserranoroberto effectsofatopicalgelcontainingchitosan02chlorhexidineallantoinanddespanthenolonthewoundhealingprocesssubsequenttoimpactedlowerthirdmolarextraction
AT gutierrezcorralesaida effectsofatopicalgelcontainingchitosan02chlorhexidineallantoinanddespanthenolonthewoundhealingprocesssubsequenttoimpactedlowerthirdmolarextraction
AT gutierrezperezjoseluis effectsofatopicalgelcontainingchitosan02chlorhexidineallantoinanddespanthenolonthewoundhealingprocesssubsequenttoimpactedlowerthirdmolarextraction
AT torreslagaresdaniel effectsofatopicalgelcontainingchitosan02chlorhexidineallantoinanddespanthenolonthewoundhealingprocesssubsequenttoimpactedlowerthirdmolarextraction