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Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients
BACKGROUND: Malnutrition in gastrectomized patients receiving chemotherapy is associated with the susceptibility to chemotherapy-related adverse events. This study evaluated pre-operative nutritional status-related indices associated with adverse events in post-operation gastric cancer patients rece...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116147/ https://www.ncbi.nlm.nih.gov/pubmed/27863481 http://dx.doi.org/10.1186/s12885-016-2934-5 |
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author | Seo, Seung Hee Kim, Sung-Eun Kang, Yoon-Koo Ryoo, Baek-Yeol Ryu, Min-Hee Jeong, Jae Ho Kang, Shin Sook Yang, Mihi Lee, Jung Eun Sung, Mi-Kyung |
author_facet | Seo, Seung Hee Kim, Sung-Eun Kang, Yoon-Koo Ryoo, Baek-Yeol Ryu, Min-Hee Jeong, Jae Ho Kang, Shin Sook Yang, Mihi Lee, Jung Eun Sung, Mi-Kyung |
author_sort | Seo, Seung Hee |
collection | PubMed |
description | BACKGROUND: Malnutrition in gastrectomized patients receiving chemotherapy is associated with the susceptibility to chemotherapy-related adverse events. This study evaluated pre-operative nutritional status-related indices associated with adverse events in post-operation gastric cancer patients receiving chemotherapy. METHODS: Medical records of 234 gastrectomized patients under adjuvant tegafur/gimeracil/oteracil chemotherapy with extended lymph node dissection were analyzed. Nutritional status assessment included Patient-Generated Subjective Global Assessment (PG-SGA), body weight, body mass index, serum albumin concentration, and Nutrition Risk Index (NRI). Chemotherapy-originated adverse events were determined using Common Terminology Criteria for Adverse Events. RESULTS: PG-SGA indicated 59% of the patients were malnourished, and 27.8% of the patients revealed serious malnutrition with PG-SGA score of ≥9. Fifteen % of patients lost ≥10% of the initial body weight, 14.5% of the patients had hypoalbuminemia (<3.5 g/dL), and 66.2% had NRI score less than 97.5 indicating moderate to severe malnutrition. Hematological adverse events were present in 94% (≥grade 1) and 16.2% (≥grade 3). Non-hematological adverse events occurred in 95.7% (≥grade1) and 16.7% (≥grade 3) of the patients. PG-SGA and NRI score was not associated with treatment-induced adverse events. Multivariate analyses indicated that female, low body mass index, and hypoalbuminemia were independent risk factors for grade 3/4 hematological adverse events. Age was an independent risk factor for grade 3/4 non-hematological adverse events. Neutropenia was the most frequently occurring adverse event, and associated risk factors were female, total gastrectomy, and hypoalbuminemia. CONCLUSIONS: Hypoalbuminemia, not PG-SGA or NRI may predict chemotherapy-induced adverse events in gastrectomized cancer patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-016-2934-5) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5116147 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-51161472016-11-25 Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients Seo, Seung Hee Kim, Sung-Eun Kang, Yoon-Koo Ryoo, Baek-Yeol Ryu, Min-Hee Jeong, Jae Ho Kang, Shin Sook Yang, Mihi Lee, Jung Eun Sung, Mi-Kyung BMC Cancer Research Article BACKGROUND: Malnutrition in gastrectomized patients receiving chemotherapy is associated with the susceptibility to chemotherapy-related adverse events. This study evaluated pre-operative nutritional status-related indices associated with adverse events in post-operation gastric cancer patients receiving chemotherapy. METHODS: Medical records of 234 gastrectomized patients under adjuvant tegafur/gimeracil/oteracil chemotherapy with extended lymph node dissection were analyzed. Nutritional status assessment included Patient-Generated Subjective Global Assessment (PG-SGA), body weight, body mass index, serum albumin concentration, and Nutrition Risk Index (NRI). Chemotherapy-originated adverse events were determined using Common Terminology Criteria for Adverse Events. RESULTS: PG-SGA indicated 59% of the patients were malnourished, and 27.8% of the patients revealed serious malnutrition with PG-SGA score of ≥9. Fifteen % of patients lost ≥10% of the initial body weight, 14.5% of the patients had hypoalbuminemia (<3.5 g/dL), and 66.2% had NRI score less than 97.5 indicating moderate to severe malnutrition. Hematological adverse events were present in 94% (≥grade 1) and 16.2% (≥grade 3). Non-hematological adverse events occurred in 95.7% (≥grade1) and 16.7% (≥grade 3) of the patients. PG-SGA and NRI score was not associated with treatment-induced adverse events. Multivariate analyses indicated that female, low body mass index, and hypoalbuminemia were independent risk factors for grade 3/4 hematological adverse events. Age was an independent risk factor for grade 3/4 non-hematological adverse events. Neutropenia was the most frequently occurring adverse event, and associated risk factors were female, total gastrectomy, and hypoalbuminemia. CONCLUSIONS: Hypoalbuminemia, not PG-SGA or NRI may predict chemotherapy-induced adverse events in gastrectomized cancer patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-016-2934-5) contains supplementary material, which is available to authorized users. BioMed Central 2016-11-18 /pmc/articles/PMC5116147/ /pubmed/27863481 http://dx.doi.org/10.1186/s12885-016-2934-5 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Seo, Seung Hee Kim, Sung-Eun Kang, Yoon-Koo Ryoo, Baek-Yeol Ryu, Min-Hee Jeong, Jae Ho Kang, Shin Sook Yang, Mihi Lee, Jung Eun Sung, Mi-Kyung Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients |
title | Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients |
title_full | Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients |
title_fullStr | Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients |
title_full_unstemmed | Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients |
title_short | Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients |
title_sort | association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116147/ https://www.ncbi.nlm.nih.gov/pubmed/27863481 http://dx.doi.org/10.1186/s12885-016-2934-5 |
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