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Prevalence of transfusion transmissible infections in blood donors of Pakistan

BACKGROUND: Transfusion-transmitted infections threaten the safety of patients requiring blood transfusion, which in turn imposes serious challenges for the availability of safe blood products that are still affordable in health care systems with limited resources. The aim of the study was to determ...

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Autores principales: Arshad, Aisha, Borhany, Munira, Anwar, Nida, Naseer, Imran, Ansari, Rehan, Boota, Samson, Fatima, Naveena, Zaidi, Mustansir, Shamsi, Tahir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116208/
https://www.ncbi.nlm.nih.gov/pubmed/27891232
http://dx.doi.org/10.1186/s12878-016-0068-2
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author Arshad, Aisha
Borhany, Munira
Anwar, Nida
Naseer, Imran
Ansari, Rehan
Boota, Samson
Fatima, Naveena
Zaidi, Mustansir
Shamsi, Tahir
author_facet Arshad, Aisha
Borhany, Munira
Anwar, Nida
Naseer, Imran
Ansari, Rehan
Boota, Samson
Fatima, Naveena
Zaidi, Mustansir
Shamsi, Tahir
author_sort Arshad, Aisha
collection PubMed
description BACKGROUND: Transfusion-transmitted infections threaten the safety of patients requiring blood transfusion, which in turn imposes serious challenges for the availability of safe blood products that are still affordable in health care systems with limited resources. The aim of the study was to determine the prevalence of transfusion-transmitted infections in blood donors and to evaluate the demographic characteristics of reactive and non-reactive blood donors. METHODS: A prospective cohort study was conducted at our institute in Karachi, Pakistan. Donors were required to fill a detailed questionnaire and were screened for Hepatitis B, Hepatitis C, Human immunodeficiency viruses, Syphilis and Malaria by ELISA and thick film (malaria). RESULTS: Of the 16,602 blood donors, 16,557 were males and 45 females (mean age 28.6 ± 2). Nine hundred and seventy three (5.8%) donations were reactive in any screening assay, with 58 (0.35%) donations reacting in more than one assay. The prevalence of Hepatitis B, Hepatitis C, Human immunodeficiency viruses, Syphilis and Malaria was found to be 1.84, 1.7, 0.04, 2.1 and 0.07% respectively. Characteristics among the infections were evaluated and it was found that unmarried donors had a higher chance to be infected by Hepatitis B virus and Syphilis as compared to the other infections. On the other hand, construction workers and married donors were at more risk to be infected by Syphilis rather than the other infections. In case of co-infections, personnel with different occupations and marital status were infected by more than one pathogen. CONCLUSION: A substantial percentage of the blood donor’s harbored transfusion-transmitted infections. Prevention of TTIs should be the main goal right now. There is a need for stringent selection of blood donors with the emphasis on getting voluntary donations and comprehensive screening of donor’s blood for TTIs using standard methods to ensure the safety of blood recipient.
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spelling pubmed-51162082016-11-25 Prevalence of transfusion transmissible infections in blood donors of Pakistan Arshad, Aisha Borhany, Munira Anwar, Nida Naseer, Imran Ansari, Rehan Boota, Samson Fatima, Naveena Zaidi, Mustansir Shamsi, Tahir BMC Hematol Research Article BACKGROUND: Transfusion-transmitted infections threaten the safety of patients requiring blood transfusion, which in turn imposes serious challenges for the availability of safe blood products that are still affordable in health care systems with limited resources. The aim of the study was to determine the prevalence of transfusion-transmitted infections in blood donors and to evaluate the demographic characteristics of reactive and non-reactive blood donors. METHODS: A prospective cohort study was conducted at our institute in Karachi, Pakistan. Donors were required to fill a detailed questionnaire and were screened for Hepatitis B, Hepatitis C, Human immunodeficiency viruses, Syphilis and Malaria by ELISA and thick film (malaria). RESULTS: Of the 16,602 blood donors, 16,557 were males and 45 females (mean age 28.6 ± 2). Nine hundred and seventy three (5.8%) donations were reactive in any screening assay, with 58 (0.35%) donations reacting in more than one assay. The prevalence of Hepatitis B, Hepatitis C, Human immunodeficiency viruses, Syphilis and Malaria was found to be 1.84, 1.7, 0.04, 2.1 and 0.07% respectively. Characteristics among the infections were evaluated and it was found that unmarried donors had a higher chance to be infected by Hepatitis B virus and Syphilis as compared to the other infections. On the other hand, construction workers and married donors were at more risk to be infected by Syphilis rather than the other infections. In case of co-infections, personnel with different occupations and marital status were infected by more than one pathogen. CONCLUSION: A substantial percentage of the blood donor’s harbored transfusion-transmitted infections. Prevention of TTIs should be the main goal right now. There is a need for stringent selection of blood donors with the emphasis on getting voluntary donations and comprehensive screening of donor’s blood for TTIs using standard methods to ensure the safety of blood recipient. BioMed Central 2016-11-18 /pmc/articles/PMC5116208/ /pubmed/27891232 http://dx.doi.org/10.1186/s12878-016-0068-2 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Arshad, Aisha
Borhany, Munira
Anwar, Nida
Naseer, Imran
Ansari, Rehan
Boota, Samson
Fatima, Naveena
Zaidi, Mustansir
Shamsi, Tahir
Prevalence of transfusion transmissible infections in blood donors of Pakistan
title Prevalence of transfusion transmissible infections in blood donors of Pakistan
title_full Prevalence of transfusion transmissible infections in blood donors of Pakistan
title_fullStr Prevalence of transfusion transmissible infections in blood donors of Pakistan
title_full_unstemmed Prevalence of transfusion transmissible infections in blood donors of Pakistan
title_short Prevalence of transfusion transmissible infections in blood donors of Pakistan
title_sort prevalence of transfusion transmissible infections in blood donors of pakistan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116208/
https://www.ncbi.nlm.nih.gov/pubmed/27891232
http://dx.doi.org/10.1186/s12878-016-0068-2
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