Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons

BACKGROUND: Mutations in leucine-rich repeat kinase 2 (LRRK2) contribute to both familial and idiopathic forms of Parkinson’s disease (PD). Neuroinflammation is a key event in neurodegeneration and aging, and there is mounting evidence of LRRK2 involvement in inflammatory pathways. In a previous stu...

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Detalles Bibliográficos
Autores principales: López de Maturana, Rakel, Lang, Valérie, Zubiarrain, Amaia, Sousa, Amaya, Vázquez, Nerea, Gorostidi, Ana, Águila, Julio, López de Munain, Adolfo, Rodríguez, Manuel, Sánchez-Pernaute, Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116223/
https://www.ncbi.nlm.nih.gov/pubmed/27863501
http://dx.doi.org/10.1186/s12974-016-0761-x

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