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Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis

Background. The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in nonmetastatic renal cell carcinoma (non-mRCC) is controversial, although NLR has been established as a prognostic factor in several cancers. The objective of our study was to assess the prognostic significance of...

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Autores principales: Byun, Seok-Soo, Hwang, Eu Chang, Kang, Seok Ho, Hong, Sung-Hoo, Chung, Jinsoo, Kwon, Tae Gyun, Kim, Hyeon Hoe, Kwak, Cheol, Kim, Yong-June, Lee, Won Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116355/
https://www.ncbi.nlm.nih.gov/pubmed/27891517
http://dx.doi.org/10.1155/2016/5634148
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author Byun, Seok-Soo
Hwang, Eu Chang
Kang, Seok Ho
Hong, Sung-Hoo
Chung, Jinsoo
Kwon, Tae Gyun
Kim, Hyeon Hoe
Kwak, Cheol
Kim, Yong-June
Lee, Won Ki
author_facet Byun, Seok-Soo
Hwang, Eu Chang
Kang, Seok Ho
Hong, Sung-Hoo
Chung, Jinsoo
Kwon, Tae Gyun
Kim, Hyeon Hoe
Kwak, Cheol
Kim, Yong-June
Lee, Won Ki
author_sort Byun, Seok-Soo
collection PubMed
description Background. The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in nonmetastatic renal cell carcinoma (non-mRCC) is controversial, although NLR has been established as a prognostic factor in several cancers. The objective of our study was to assess the prognostic significance of preoperative NLR in non-mRCC, based on a large, multicenter cohort analysis. Methods. Totally, 1,284 non-mRCC patients undergoing surgery were enrolled from six institutions between 2000 and 2014. Recurrence-free survival (RFS) and cancer-specific survival (CSS) were calculated, and the prognostic significance of NLR was evaluated. Results. Patients with higher NLR had larger tumors (p < 0.001), higher T stage (p < 0.001), worse Eastern Cooperative Oncology Group performance status (p < 0.001), worse symptoms (p = 0.003), sarcomatoid differentiation (p = 0.004), and tumor necrosis (p < 0.001). The 5-year RFS and CSS rates were significantly lower in patients with high NLR than in those with low NLR (each p < 0.001). Multivariate analysis identified NLR to be an independent predictor of RFS and CSS (each p < 0.05). Moreover, predictive accuracy of multivariate models for RFS and CSS increased by 2.2% and 4.2%, respectively, with NLR inclusion. Conclusions. Higher NLR was associated with worse clinical behavior of non-mRCC. Also, NLR was a significant prognostic factor of both RFS and CSS.
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spelling pubmed-51163552016-11-27 Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis Byun, Seok-Soo Hwang, Eu Chang Kang, Seok Ho Hong, Sung-Hoo Chung, Jinsoo Kwon, Tae Gyun Kim, Hyeon Hoe Kwak, Cheol Kim, Yong-June Lee, Won Ki Biomed Res Int Research Article Background. The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in nonmetastatic renal cell carcinoma (non-mRCC) is controversial, although NLR has been established as a prognostic factor in several cancers. The objective of our study was to assess the prognostic significance of preoperative NLR in non-mRCC, based on a large, multicenter cohort analysis. Methods. Totally, 1,284 non-mRCC patients undergoing surgery were enrolled from six institutions between 2000 and 2014. Recurrence-free survival (RFS) and cancer-specific survival (CSS) were calculated, and the prognostic significance of NLR was evaluated. Results. Patients with higher NLR had larger tumors (p < 0.001), higher T stage (p < 0.001), worse Eastern Cooperative Oncology Group performance status (p < 0.001), worse symptoms (p = 0.003), sarcomatoid differentiation (p = 0.004), and tumor necrosis (p < 0.001). The 5-year RFS and CSS rates were significantly lower in patients with high NLR than in those with low NLR (each p < 0.001). Multivariate analysis identified NLR to be an independent predictor of RFS and CSS (each p < 0.05). Moreover, predictive accuracy of multivariate models for RFS and CSS increased by 2.2% and 4.2%, respectively, with NLR inclusion. Conclusions. Higher NLR was associated with worse clinical behavior of non-mRCC. Also, NLR was a significant prognostic factor of both RFS and CSS. Hindawi Publishing Corporation 2016 2016-11-06 /pmc/articles/PMC5116355/ /pubmed/27891517 http://dx.doi.org/10.1155/2016/5634148 Text en Copyright © 2016 Seok-Soo Byun et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Byun, Seok-Soo
Hwang, Eu Chang
Kang, Seok Ho
Hong, Sung-Hoo
Chung, Jinsoo
Kwon, Tae Gyun
Kim, Hyeon Hoe
Kwak, Cheol
Kim, Yong-June
Lee, Won Ki
Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis
title Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis
title_full Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis
title_fullStr Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis
title_full_unstemmed Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis
title_short Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis
title_sort prognostic significance of preoperative neutrophil-to-lymphocyte ratio in nonmetastatic renal cell carcinoma: a large, multicenter cohort analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116355/
https://www.ncbi.nlm.nih.gov/pubmed/27891517
http://dx.doi.org/10.1155/2016/5634148
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