Successful treatment of a 67-year-old woman with urethral adenocarcinoma with the use of external beam radiotherapy and image guided adaptive interstitial brachytherapy

Primary urethral cancer (PUC) is a very rare disease. This case report illustrates a successful treatment approach of a 67-year-old woman with a urethral adenocarcinoma selected for an organ preserving treatment with external beam radiotherapy (EBRT) and interstitial brachytherapy (BT) boost, using...

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Detalles Bibliográficos
Autores principales: Mujkanovic, Jasmin, Tanderup, Kari, Agerbæk, Mads, Bisgaard, Ulla, Høyer, Søren, Lindegaard, Jacob Christian, Fokdal, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116457/
https://www.ncbi.nlm.nih.gov/pubmed/27895686
http://dx.doi.org/10.5114/jcb.2016.63461
Descripción
Sumario:Primary urethral cancer (PUC) is a very rare disease. This case report illustrates a successful treatment approach of a 67-year-old woman with a urethral adenocarcinoma selected for an organ preserving treatment with external beam radiotherapy (EBRT) and interstitial brachytherapy (BT) boost, using the GEC-ESTRO target concept originally designed for locally advanced cervical cancer (LACC). Treatment included EBRT with 45 Gy in 25 fractions followed by image guided adaptive interstitial BT (IGABT) with a pulsed-dose-rate (PDR) BT boost with 30 Gy in 50 hourly pulses. The D(90) for CTV(HR) was 79.1 Gy in EQD2(3). At 24 months follow-up, the patient was recurrence free and without treatment related side effects.

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