Cargando…
Switching Adolescent High-Fat Diet to Adult Control Diet Restores Neurocognitive Alterations
In addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive and emotional outcomes. Its growing prevalence in adolescents is particularly alarming since this is a period of ongoing maturation for brain structures (including the hippocampus and amygdala) and fo...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116459/ https://www.ncbi.nlm.nih.gov/pubmed/27917115 http://dx.doi.org/10.3389/fnbeh.2016.00225 |
_version_ | 1782468660904853504 |
---|---|
author | Boitard, Chloé Parkes, Shauna L. Cavaroc, Amandine Tantot, Frédéric Castanon, Nathalie Layé, Sophie Tronel, Sophie Pacheco-Lopez, Gustavo Coutureau, Etienne Ferreira, Guillaume |
author_facet | Boitard, Chloé Parkes, Shauna L. Cavaroc, Amandine Tantot, Frédéric Castanon, Nathalie Layé, Sophie Tronel, Sophie Pacheco-Lopez, Gustavo Coutureau, Etienne Ferreira, Guillaume |
author_sort | Boitard, Chloé |
collection | PubMed |
description | In addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive and emotional outcomes. Its growing prevalence in adolescents is particularly alarming since this is a period of ongoing maturation for brain structures (including the hippocampus and amygdala) and for the hypothalamic-pituitary-adrenal (HPA) stress axis, which is required for cognitive and emotional processing. We recently demonstrated that adolescent, but not adult, high-fat diet (HF) exposure leads to impaired hippocampal function and enhanced amygdala function through HPA axis alteration (Boitard et al., 2012, 2014, 2015). Here, we assessed whether the effects of adolescent HF consumption on brain function are permanent or reversible. After adolescent exposure to HF, switching to a standard control diet restored levels of hippocampal neurogenesis and normalized enhanced HPA axis reactivity, amygdala activity and avoidance memory. Therefore, while the adolescent period is highly vulnerable to the deleterious effects of diet-induced obesity, adult exposure to a standard diet appears sufficient to reverse alterations of brain function. |
format | Online Article Text |
id | pubmed-5116459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-51164592016-12-02 Switching Adolescent High-Fat Diet to Adult Control Diet Restores Neurocognitive Alterations Boitard, Chloé Parkes, Shauna L. Cavaroc, Amandine Tantot, Frédéric Castanon, Nathalie Layé, Sophie Tronel, Sophie Pacheco-Lopez, Gustavo Coutureau, Etienne Ferreira, Guillaume Front Behav Neurosci Neuroscience In addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive and emotional outcomes. Its growing prevalence in adolescents is particularly alarming since this is a period of ongoing maturation for brain structures (including the hippocampus and amygdala) and for the hypothalamic-pituitary-adrenal (HPA) stress axis, which is required for cognitive and emotional processing. We recently demonstrated that adolescent, but not adult, high-fat diet (HF) exposure leads to impaired hippocampal function and enhanced amygdala function through HPA axis alteration (Boitard et al., 2012, 2014, 2015). Here, we assessed whether the effects of adolescent HF consumption on brain function are permanent or reversible. After adolescent exposure to HF, switching to a standard control diet restored levels of hippocampal neurogenesis and normalized enhanced HPA axis reactivity, amygdala activity and avoidance memory. Therefore, while the adolescent period is highly vulnerable to the deleterious effects of diet-induced obesity, adult exposure to a standard diet appears sufficient to reverse alterations of brain function. Frontiers Media S.A. 2016-11-21 /pmc/articles/PMC5116459/ /pubmed/27917115 http://dx.doi.org/10.3389/fnbeh.2016.00225 Text en Copyright © 2016 Boitard, Parkes, Cavaroc, Tantot, Castanon, Layé, Tronel, Pacheco-Lopez, Coutureau and Ferreira. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Boitard, Chloé Parkes, Shauna L. Cavaroc, Amandine Tantot, Frédéric Castanon, Nathalie Layé, Sophie Tronel, Sophie Pacheco-Lopez, Gustavo Coutureau, Etienne Ferreira, Guillaume Switching Adolescent High-Fat Diet to Adult Control Diet Restores Neurocognitive Alterations |
title | Switching Adolescent High-Fat Diet to Adult Control Diet Restores Neurocognitive Alterations |
title_full | Switching Adolescent High-Fat Diet to Adult Control Diet Restores Neurocognitive Alterations |
title_fullStr | Switching Adolescent High-Fat Diet to Adult Control Diet Restores Neurocognitive Alterations |
title_full_unstemmed | Switching Adolescent High-Fat Diet to Adult Control Diet Restores Neurocognitive Alterations |
title_short | Switching Adolescent High-Fat Diet to Adult Control Diet Restores Neurocognitive Alterations |
title_sort | switching adolescent high-fat diet to adult control diet restores neurocognitive alterations |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116459/ https://www.ncbi.nlm.nih.gov/pubmed/27917115 http://dx.doi.org/10.3389/fnbeh.2016.00225 |
work_keys_str_mv | AT boitardchloe switchingadolescenthighfatdiettoadultcontroldietrestoresneurocognitivealterations AT parkesshaunal switchingadolescenthighfatdiettoadultcontroldietrestoresneurocognitivealterations AT cavarocamandine switchingadolescenthighfatdiettoadultcontroldietrestoresneurocognitivealterations AT tantotfrederic switchingadolescenthighfatdiettoadultcontroldietrestoresneurocognitivealterations AT castanonnathalie switchingadolescenthighfatdiettoadultcontroldietrestoresneurocognitivealterations AT layesophie switchingadolescenthighfatdiettoadultcontroldietrestoresneurocognitivealterations AT tronelsophie switchingadolescenthighfatdiettoadultcontroldietrestoresneurocognitivealterations AT pachecolopezgustavo switchingadolescenthighfatdiettoadultcontroldietrestoresneurocognitivealterations AT coutureauetienne switchingadolescenthighfatdiettoadultcontroldietrestoresneurocognitivealterations AT ferreiraguillaume switchingadolescenthighfatdiettoadultcontroldietrestoresneurocognitivealterations |