Cargando…

Tropisetron Protects Against Acetaminophen-Induced Liver Injury via Suppressing Hepatic Oxidative Stress and Modulating the Activation of JNK/ERK MAPK Pathways

Objectives. To investigate the protective effects of tropisetron on acetaminophen- (APAP-) induced liver injury in a mice model. Methods. C57BL/6 male mice were given tropisetron (0.3 to 10 mg/kg) 30 minutes before a hepatotoxic dose of acetaminophen (300 mg/kg) intraperitoneally. Twenty hours after...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Fu-Chao, Lee, Hung-Chen, Liao, Chia-Chih, Li, Allen H., Yu, Huang-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116490/ https://www.ncbi.nlm.nih.gov/pubmed/27891510 http://dx.doi.org/10.1155/2016/1952947

Ejemplares similares

Protective Effect of Tropisetron on Rodent Hepatic Injury after Trauma-Hemorrhagic Shock through P38 MAPK-Dependent Hemeoxygenase-1 Expression
por: Liu, Fu-Chao, et al.
Publicado: (2012)

The MAP2K4/JNK/c-Jun Signaling Pathway Plays A Key Role In Dexmedetomidine Protection Against Acetaminophen-Induced Liver Toxicity
por: Chou, An-Hsun, et al.
Publicado: (2019)

ERK/NF-kB/COX-2 Signaling Pathway Plays a Key Role in Curcumin Protection against Acetaminophen-Induced Liver Injury
por: Chou, An-Hsun, et al.
Publicado: (2023)

Tropisetron Facilitates Footshock Suppression of Compulsive Cocaine Seeking
por: Zhou, Yue-Qing, et al.
Publicado: (2019)

Role of NADPH Oxidase-Derived ROS-Mediated IL-6/STAT3 and MAPK/NF-κB Signaling Pathways in Protective Effect of Corilagin against Acetaminophen-Induced Liver Injury in Mice
por: Liu, Fu-Chao, et al.
Publicado: (2023)

CD5L deficiency attenuate acetaminophen-induced liver damage in mice via regulation of JNK and ERK signaling pathway
por: Li, Mengjing, et al.
Publicado: (2021)

The Timing and Effects of Low-Dose Ethanol Treatment on Acetaminophen-Induced Liver Injury
por: Liu, Fu-Chao, et al.
Publicado: (2021)

Urantide decreases hepatic steatosis in rats with experimental atherosclerosis via the MAPK/Erk/JNK pathway
por: Cui, Haipeng, et al.
Publicado: (2021)

Detrimental effects of tropisetron on permanent ischemic stroke in the rat
por: Candelario-Jalil, Eduardo, et al.
Publicado: (2008)

Paeoniflorin Protects against Acetaminophen-Induced Liver Injury in Mice via JNK Signaling Pathway
por: Deng, Xinyu, et al.
Publicado: (2022)

Baicalin Attenuates IL-17-Mediated Acetaminophen-Induced Liver Injury in a Mouse Model
por: Liao, Chia-Chih, et al.
Publicado: (2016)

Simultaneous Determination of Dexamethasone, Ondansetron, Granisetron, Tropisetron, and Azasetron in Infusion Samples by HPLC with DAD Detection
por: Chen, Fu-chao, et al.
Publicado: (2017)

Stability of Butorphanol–Tropisetron Mixtures in 0.9% Sodium Chloride Injection for Patient-Controlled Analgesia Use
por: Chen, Fu-Chao, et al.
Publicado: (2015)

Sodium Ferulate Protects against Angiotensin II-Induced Cardiac Hypertrophy in Mice by Regulating the MAPK/ERK and JNK Pathways
por: Hu, Bo, et al.
Publicado: (2017)

SAK-HV Decreases the Self-Ubiquitination of MEKK1 to Promote Macrophage Proliferation via MAPK/ERK and JNK Pathways
por: Zhang, Chao, et al.
Publicado: (2017)

Activation of Erk and JNK MAPK pathways by acute swim stress in rat brain regions
por: Shen, Chang-peng, et al.
Publicado: (2004)

A randomised, double-blind, placebo-controlled trial of tropisetron in patients with schizophrenia
por: Shiina, Akihiro, et al.
Publicado: (2010)

Granisetron versus tropisetron in the prevention of postoperative nausea and vomiting after total thyroidectomy
por: Papadima, Artemisia, et al.
Publicado: (2013)

Tropisetron Preconditioning Decreases Myocardial Biomarkers in Patients Undergoing Heart Valve Replacement Surgery
por: Yu, Di, et al.
Publicado: (2022)

Effect of preoperative tropisetron treatment on postoperative cognitive function: A retrospective cohort study
por: Zhang, Dongbin, et al.
Publicado: (2022)

PAGE4 promotes prostate cancer cells survive under oxidative stress through modulating MAPK/JNK/ERK pathway
por: Lv, Chengcheng, et al.
Publicado: (2019)

Involvement of AMPKα and MAPK-ERK/-JNK Signals in Docetaxel-Induced Human Tongue Squamous Cell Carcinoma Cell Apoptosis
por: Su, Chin-Chuan, et al.
Publicado: (2022)

CLCA2 overexpression suppresses epithelial-to-mesenchymal transition in cervical cancer cells through inactivation of ERK/JNK/p38-MAPK signaling pathways
por: Xin, Wenhu, et al.
Publicado: (2022)

Suppression of Hepatic Epithelial-to-Mesenchymal Transition by Melittin via Blocking of TGFβ/Smad and MAPK-JNK Signaling Pathways
por: Park, Ji-Hyun, et al.
Publicado: (2017)

Comparison of ondansetron, tropisetron, and palonosetron for the prevention of postoperative nausea and vomiting after middle ear surgery
por: Aydin, Ahmet, et al.
Publicado: (2019)

Effect of Tropisetron on Prevention of Emergence Delirium in Patients After Noncardiac Surgery: A Trial Protocol
por: Sun, Yi, et al.
Publicado: (2020)

In vitro effects of tropisetron and granisetron against Echinococcus granulosus (s.s.) protoscoleces by involvement of calcineurin and calmodulin
por: Shiee, Mohammad Reza, et al.
Publicado: (2021)

PEA15 promotes liver metastasis of colorectal cancer by upregulating the ERK/MAPK signaling pathway
por: Tang, Bo, et al.
Publicado: (2019)

A sestrin-dependent Erk/Jnk/p38 MAPK activation complex inhibits immunity during ageing
por: Lanna, Alessio, et al.
Publicado: (2017)

Tetramethylpyrazine protects against high glucose-induced vascular smooth muscle cell injury through inhibiting the phosphorylation of JNK, p38MAPK, and ERK
por: Liu, Yutao, et al.
Publicado: (2018)

Auriculatone Sulfate Effectively Protects Mice Against Acetaminophen-Induced Liver Injury
por: Lin, Liangcai, et al.
Publicado: (2019)

[Retracted] PEA15 promotes liver metastasis of colorectal cancer by upregulating the ERK/MAPK signaling pathway
por: Tang, Bo, et al.
Publicado: (2023)

Compatibility and stability of dezocine and tropisetron in 0.9% sodium chloride injection for patient-controlled analgesia administration
por: Chen, Peng, et al.
Publicado: (2018)

Comparison of ondansetron and tropisetron in preventing postoperative nausea and vomiting: A meta-analysis of randomized controlled trials
por: Wang, Rui, et al.
Publicado: (2021)

IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NF-κB pathway and reduction of JNK in HNSCC
por: Chan, Leong-Perng, et al.
Publicado: (2017)

BHLHE41 suppresses MCF‐7 cell invasion via MAPK/JNK pathway
por: Zhang, Di, et al.
Publicado: (2020)

Aprepitant Inhibits JNK and p38/MAPK to Attenuate Inflammation and Suppresses Inflammatory Pain
por: Yang, Yang, et al.
Publicado: (2022)

MAPK/ERK and JNK pathways regulate lipid synthesis and cell growth of Chlamydomonas reinhardtii under osmotic stress, respectively
por: Yang, Ahreum, et al.
Publicado: (2018)

Chlorogenic Acid Attenuates Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice through MAPK/ERK/JNK Pathway
por: Gao, Wenyan, et al.
Publicado: (2019)

MAPK-ERK Pathway
por: Park, Jong-In
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_aao83e0p2m4ugnrj1b607a6eq2