Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features

We present the case of a 43-year-old lady who presented with headaches, visual impairment, and seizures, progressing rapidly over the course of a few weeks. Extensive workup excluded an inflammatory or infectious cause. Imaging studies revealed diffuse thickening of the leptomeninges and serial CSF...

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Detalles Bibliográficos
Autores principales: Ahmad, Ehtasham, Mohamed, Mohamed, Vrettos, Apostolos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116496/
https://www.ncbi.nlm.nih.gov/pubmed/27891270
http://dx.doi.org/10.1155/2016/5016840
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author Ahmad, Ehtasham
Mohamed, Mohamed
Vrettos, Apostolos
author_facet Ahmad, Ehtasham
Mohamed, Mohamed
Vrettos, Apostolos
author_sort Ahmad, Ehtasham
collection PubMed
description We present the case of a 43-year-old lady who presented with headaches, visual impairment, and seizures, progressing rapidly over the course of a few weeks. Extensive workup excluded an inflammatory or infectious cause. Imaging studies revealed diffuse thickening of the leptomeninges and serial CSF analysis showed raised opening pressures and increased protein levels. A diagnostic biopsy of the lower thoracic dura confirmed the diagnosis of primary diffuse leptomeningeal gliomatosis (PDGL). She was managed supportively for her symptoms and unfortunately she passed away a few weeks later.
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spelling pubmed-51164962016-11-27 Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features Ahmad, Ehtasham Mohamed, Mohamed Vrettos, Apostolos Case Rep Neurol Med Case Report We present the case of a 43-year-old lady who presented with headaches, visual impairment, and seizures, progressing rapidly over the course of a few weeks. Extensive workup excluded an inflammatory or infectious cause. Imaging studies revealed diffuse thickening of the leptomeninges and serial CSF analysis showed raised opening pressures and increased protein levels. A diagnostic biopsy of the lower thoracic dura confirmed the diagnosis of primary diffuse leptomeningeal gliomatosis (PDGL). She was managed supportively for her symptoms and unfortunately she passed away a few weeks later. Hindawi Publishing Corporation 2016 2016-11-07 /pmc/articles/PMC5116496/ /pubmed/27891270 http://dx.doi.org/10.1155/2016/5016840 Text en Copyright © 2016 Ehtasham Ahmad et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ahmad, Ehtasham
Mohamed, Mohamed
Vrettos, Apostolos
Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features
title Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features
title_full Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features
title_fullStr Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features
title_full_unstemmed Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features
title_short Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features
title_sort primary diffuse leptomeningeal gliomatosis: radiological/pathological features
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116496/
https://www.ncbi.nlm.nih.gov/pubmed/27891270
http://dx.doi.org/10.1155/2016/5016840
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AT mohamedmohamed primarydiffuseleptomeningealgliomatosisradiologicalpathologicalfeatures
AT vrettosapostolos primarydiffuseleptomeningealgliomatosisradiologicalpathologicalfeatures

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