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Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis

A meta-analysis was carried out to compare the efficacy and safety of capecitabine plus radiation with 5-fluorouracil (5-FU) plus radiotherapy (RT) as neoadjuvant treatment in locally advanced rectal cancer (LARC). We searched the Cochrane database, Ovid, Medline, Embase, ISI databases, and Chinese...

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Autores principales: Liu, Guo-Chen, Yan, Jun-Ping, He, Qing, An, Xin, Pan, Zhi-Zhong, Ding, Pei-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116508/
https://www.ncbi.nlm.nih.gov/pubmed/27891147
http://dx.doi.org/10.1155/2016/1798285
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author Liu, Guo-Chen
Yan, Jun-Ping
He, Qing
An, Xin
Pan, Zhi-Zhong
Ding, Pei-Rong
author_facet Liu, Guo-Chen
Yan, Jun-Ping
He, Qing
An, Xin
Pan, Zhi-Zhong
Ding, Pei-Rong
author_sort Liu, Guo-Chen
collection PubMed
description A meta-analysis was carried out to compare the efficacy and safety of capecitabine plus radiation with 5-fluorouracil (5-FU) plus radiotherapy (RT) as neoadjuvant treatment in locally advanced rectal cancer (LARC). We searched the Cochrane database, Ovid, Medline, Embase, ISI databases, and Chinese Biomedical Literature Database between January 1998 and October 2014. Trials of capecitabine compared with 5-FU plus RT as neoadjuvant treatment for LARC were considered for inclusion. RevMan software was used to analyze these data. Nine trials were included in this meta-analysis, which covered a total of 3141 patients. The meta-analysis showed that capecitabine group had statistically significant better pCR rates (OR, 1.34; 95% CI, 1.10–1.64; P = 0.003), T downstaging rates (OR, 1.58; 95% CI, 1.22–2.06; P = 0.0007), N downstaging rates (OR, 2.06; 95% CI, 1.34–3.16; P = 0.001), less distant metastasis (OR, 0.63; 95% CI, 0.44–0.88; P = 0.007), and lowered leucocytes (OR, 0.25; 95% CI, 0.11–0.54; P = 0.0005), but with higher incidence of hand-foot syndrome (HFS) (OR, 4.43; 95% CI, 1.59–12.33; P = 0.004). Capecitabine was more efficient than 5-FU in terms of tumor response in neoadjuvant treatment for patients with LARC and favourably low toxicity with the exception of HFS.
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spelling pubmed-51165082016-11-27 Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis Liu, Guo-Chen Yan, Jun-Ping He, Qing An, Xin Pan, Zhi-Zhong Ding, Pei-Rong Gastroenterol Res Pract Review Article A meta-analysis was carried out to compare the efficacy and safety of capecitabine plus radiation with 5-fluorouracil (5-FU) plus radiotherapy (RT) as neoadjuvant treatment in locally advanced rectal cancer (LARC). We searched the Cochrane database, Ovid, Medline, Embase, ISI databases, and Chinese Biomedical Literature Database between January 1998 and October 2014. Trials of capecitabine compared with 5-FU plus RT as neoadjuvant treatment for LARC were considered for inclusion. RevMan software was used to analyze these data. Nine trials were included in this meta-analysis, which covered a total of 3141 patients. The meta-analysis showed that capecitabine group had statistically significant better pCR rates (OR, 1.34; 95% CI, 1.10–1.64; P = 0.003), T downstaging rates (OR, 1.58; 95% CI, 1.22–2.06; P = 0.0007), N downstaging rates (OR, 2.06; 95% CI, 1.34–3.16; P = 0.001), less distant metastasis (OR, 0.63; 95% CI, 0.44–0.88; P = 0.007), and lowered leucocytes (OR, 0.25; 95% CI, 0.11–0.54; P = 0.0005), but with higher incidence of hand-foot syndrome (HFS) (OR, 4.43; 95% CI, 1.59–12.33; P = 0.004). Capecitabine was more efficient than 5-FU in terms of tumor response in neoadjuvant treatment for patients with LARC and favourably low toxicity with the exception of HFS. Hindawi Publishing Corporation 2016 2016-11-07 /pmc/articles/PMC5116508/ /pubmed/27891147 http://dx.doi.org/10.1155/2016/1798285 Text en Copyright © 2016 Guo-Chen Liu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Liu, Guo-Chen
Yan, Jun-Ping
He, Qing
An, Xin
Pan, Zhi-Zhong
Ding, Pei-Rong
Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis
title Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis
title_full Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis
title_fullStr Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis
title_full_unstemmed Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis
title_short Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis
title_sort effect of neoadjuvant chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116508/
https://www.ncbi.nlm.nih.gov/pubmed/27891147
http://dx.doi.org/10.1155/2016/1798285
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