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The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδ

We have previously shown that ES-62, a phosphorylcholine (PC)-containing glycoprotein secreted by the parasitic filarial nematode Acanthocheilonema viteae targets dendritic cell (DC) responses, specifically by suppressing TLR4 signalling to inhibit Th1/Th17-driven inflammation. We have now investiga...

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Detalles Bibliográficos
Autores principales:	Eason, Russell J., Bell, Kara S., Marshall, Fraser A., Rodgers, David T., Pineda, Miguel A., Steiger, Christina N., Al-Riyami, Lamyaa, Harnett, William, Harnett, Margaret M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116678/ https://www.ncbi.nlm.nih.gov/pubmed/27869138 http://dx.doi.org/10.1038/srep37276

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