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Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer's disease mice
Impaired hippocampal neurogenesis is one of the early pathological features of Alzheimer's disease. Enhancing adult hippocampal neurogenesis has been pursued as a potential therapeutic strategy for Alzheimer's disease. Recent studies have demonstrated that environmental novelty activates β...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116841/ https://www.ncbi.nlm.nih.gov/pubmed/27904493 http://dx.doi.org/10.4103/1673-5374.193241 |
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author | Chai, Gao-shang Wang, Yang-yang Yasheng, Amina Zhao, Peng |
author_facet | Chai, Gao-shang Wang, Yang-yang Yasheng, Amina Zhao, Peng |
author_sort | Chai, Gao-shang |
collection | PubMed |
description | Impaired hippocampal neurogenesis is one of the early pathological features of Alzheimer's disease. Enhancing adult hippocampal neurogenesis has been pursued as a potential therapeutic strategy for Alzheimer's disease. Recent studies have demonstrated that environmental novelty activates β(2)-adrenergic signaling and prevents the memory impairment induced by amyloid-β oligomers. Here, we hypothesized that β(2)-adrenoceptor activation would enhance neurogenesis and ameliorate memory deficits in Alzheimer's disease. To test this hypothesis, we investigated the effects and mechanisms of action of β(2)-adrenoceptor activation on neurogenesis and memory in amyloid precursor protein/presenilin 1 (APP/PS1) mice using the agonist clenbuterol (intraperitoneal injection, 2 mg/kg). We found that β(2)-adrenoceptor activation enhanced hippocampal neurogenesis, ameliorated memory deficits, and increased dendritic branching and the density of dendritic spines. These effects were associated with the upregulation of postsynaptic density 95, synapsin 1 and synaptophysin in APP/PS1 mice. Furthermore, β(2)-adrenoceptor activation decreased cerebral amyloid plaques by decreasing APP phosphorylation at Thr668. These findings suggest that β(2)-adrenoceptor activation enhances neurogenesis and ameliorates memory deficits in APP/PS1 mice. |
format | Online Article Text |
id | pubmed-5116841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-51168412016-11-30 Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer's disease mice Chai, Gao-shang Wang, Yang-yang Yasheng, Amina Zhao, Peng Neural Regen Res Research Article Impaired hippocampal neurogenesis is one of the early pathological features of Alzheimer's disease. Enhancing adult hippocampal neurogenesis has been pursued as a potential therapeutic strategy for Alzheimer's disease. Recent studies have demonstrated that environmental novelty activates β(2)-adrenergic signaling and prevents the memory impairment induced by amyloid-β oligomers. Here, we hypothesized that β(2)-adrenoceptor activation would enhance neurogenesis and ameliorate memory deficits in Alzheimer's disease. To test this hypothesis, we investigated the effects and mechanisms of action of β(2)-adrenoceptor activation on neurogenesis and memory in amyloid precursor protein/presenilin 1 (APP/PS1) mice using the agonist clenbuterol (intraperitoneal injection, 2 mg/kg). We found that β(2)-adrenoceptor activation enhanced hippocampal neurogenesis, ameliorated memory deficits, and increased dendritic branching and the density of dendritic spines. These effects were associated with the upregulation of postsynaptic density 95, synapsin 1 and synaptophysin in APP/PS1 mice. Furthermore, β(2)-adrenoceptor activation decreased cerebral amyloid plaques by decreasing APP phosphorylation at Thr668. These findings suggest that β(2)-adrenoceptor activation enhances neurogenesis and ameliorates memory deficits in APP/PS1 mice. Medknow Publications & Media Pvt Ltd 2016-10 /pmc/articles/PMC5116841/ /pubmed/27904493 http://dx.doi.org/10.4103/1673-5374.193241 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Research Article Chai, Gao-shang Wang, Yang-yang Yasheng, Amina Zhao, Peng Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer's disease mice |
title | Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer's disease mice |
title_full | Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer's disease mice |
title_fullStr | Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer's disease mice |
title_full_unstemmed | Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer's disease mice |
title_short | Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer's disease mice |
title_sort | beta 2-adrenergic receptor activation enhances neurogenesis in alzheimer's disease mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116841/ https://www.ncbi.nlm.nih.gov/pubmed/27904493 http://dx.doi.org/10.4103/1673-5374.193241 |
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