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Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer's disease mice

Impaired hippocampal neurogenesis is one of the early pathological features of Alzheimer's disease. Enhancing adult hippocampal neurogenesis has been pursued as a potential therapeutic strategy for Alzheimer's disease. Recent studies have demonstrated that environmental novelty activates β...

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Autores principales: Chai, Gao-shang, Wang, Yang-yang, Yasheng, Amina, Zhao, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116841/
https://www.ncbi.nlm.nih.gov/pubmed/27904493
http://dx.doi.org/10.4103/1673-5374.193241
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author Chai, Gao-shang
Wang, Yang-yang
Yasheng, Amina
Zhao, Peng
author_facet Chai, Gao-shang
Wang, Yang-yang
Yasheng, Amina
Zhao, Peng
author_sort Chai, Gao-shang
collection PubMed
description Impaired hippocampal neurogenesis is one of the early pathological features of Alzheimer's disease. Enhancing adult hippocampal neurogenesis has been pursued as a potential therapeutic strategy for Alzheimer's disease. Recent studies have demonstrated that environmental novelty activates β(2)-adrenergic signaling and prevents the memory impairment induced by amyloid-β oligomers. Here, we hypothesized that β(2)-adrenoceptor activation would enhance neurogenesis and ameliorate memory deficits in Alzheimer's disease. To test this hypothesis, we investigated the effects and mechanisms of action of β(2)-adrenoceptor activation on neurogenesis and memory in amyloid precursor protein/presenilin 1 (APP/PS1) mice using the agonist clenbuterol (intraperitoneal injection, 2 mg/kg). We found that β(2)-adrenoceptor activation enhanced hippocampal neurogenesis, ameliorated memory deficits, and increased dendritic branching and the density of dendritic spines. These effects were associated with the upregulation of postsynaptic density 95, synapsin 1 and synaptophysin in APP/PS1 mice. Furthermore, β(2)-adrenoceptor activation decreased cerebral amyloid plaques by decreasing APP phosphorylation at Thr668. These findings suggest that β(2)-adrenoceptor activation enhances neurogenesis and ameliorates memory deficits in APP/PS1 mice.
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spelling pubmed-51168412016-11-30 Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer's disease mice Chai, Gao-shang Wang, Yang-yang Yasheng, Amina Zhao, Peng Neural Regen Res Research Article Impaired hippocampal neurogenesis is one of the early pathological features of Alzheimer's disease. Enhancing adult hippocampal neurogenesis has been pursued as a potential therapeutic strategy for Alzheimer's disease. Recent studies have demonstrated that environmental novelty activates β(2)-adrenergic signaling and prevents the memory impairment induced by amyloid-β oligomers. Here, we hypothesized that β(2)-adrenoceptor activation would enhance neurogenesis and ameliorate memory deficits in Alzheimer's disease. To test this hypothesis, we investigated the effects and mechanisms of action of β(2)-adrenoceptor activation on neurogenesis and memory in amyloid precursor protein/presenilin 1 (APP/PS1) mice using the agonist clenbuterol (intraperitoneal injection, 2 mg/kg). We found that β(2)-adrenoceptor activation enhanced hippocampal neurogenesis, ameliorated memory deficits, and increased dendritic branching and the density of dendritic spines. These effects were associated with the upregulation of postsynaptic density 95, synapsin 1 and synaptophysin in APP/PS1 mice. Furthermore, β(2)-adrenoceptor activation decreased cerebral amyloid plaques by decreasing APP phosphorylation at Thr668. These findings suggest that β(2)-adrenoceptor activation enhances neurogenesis and ameliorates memory deficits in APP/PS1 mice. Medknow Publications & Media Pvt Ltd 2016-10 /pmc/articles/PMC5116841/ /pubmed/27904493 http://dx.doi.org/10.4103/1673-5374.193241 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Research Article
Chai, Gao-shang
Wang, Yang-yang
Yasheng, Amina
Zhao, Peng
Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer's disease mice
title Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer's disease mice
title_full Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer's disease mice
title_fullStr Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer's disease mice
title_full_unstemmed Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer's disease mice
title_short Beta 2-adrenergic receptor activation enhances neurogenesis in Alzheimer's disease mice
title_sort beta 2-adrenergic receptor activation enhances neurogenesis in alzheimer's disease mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116841/
https://www.ncbi.nlm.nih.gov/pubmed/27904493
http://dx.doi.org/10.4103/1673-5374.193241
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