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Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa

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[Image: see text] The Gram-negative bacterial pathogen Pseudomonas aeruginosa uses three interconnected intercellular signaling systems regulated by the transcription factors LasR, RhlR, and MvfR (PqsR), which mediate bacterial cell–cell communication via small-molecule natural products and control...

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Detalles Bibliográficos
Autores principales:	Ji, Cheng, Sharma, Indrajeet, Pratihar, Debarshi, Hudson, L. Lynn, Maura, Damien, Guney, Tezcan, Rahme, Laurence G., Pesci, Everett C., Coleman, James P., Tan, Derek S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117135/ https://www.ncbi.nlm.nih.gov/pubmed/27658001 http://dx.doi.org/10.1021/acschembio.6b00575

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