Cargando…
Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain
The high comorbidity rates of posttraumatic stress disorder and chronic pain have been widely reported, but the underlying mechanisms remain unclear. Emerging evidence suggested that an excess of inflammatory immune activities in the hippocampus involved in the progression of both posttraumatic stre...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117253/ https://www.ncbi.nlm.nih.gov/pubmed/27852966 http://dx.doi.org/10.1177/1744806916679166 |
_version_ | 1782468785230315520 |
---|---|
author | Sun, Rao Zhang, Zuoxia Lei, Yishan Liu, Yue Lu, Cui’e Rong, Hui Sun, Yu’e Zhang, Wei Ma, Zhengliang Gu, Xiaoping |
author_facet | Sun, Rao Zhang, Zuoxia Lei, Yishan Liu, Yue Lu, Cui’e Rong, Hui Sun, Yu’e Zhang, Wei Ma, Zhengliang Gu, Xiaoping |
author_sort | Sun, Rao |
collection | PubMed |
description | The high comorbidity rates of posttraumatic stress disorder and chronic pain have been widely reported, but the underlying mechanisms remain unclear. Emerging evidence suggested that an excess of inflammatory immune activities in the hippocampus involved in the progression of both posttraumatic stress disorder and chronic pain. Considering that microglia are substrates underlying the initiation and propagation of the neuroimmune response, we hypothesized that stress-induced activation of hippocampal microglia may contribute to the pathogenesis of posttraumatic stress disorder-pain comorbidity. We showed that rats exposed to single prolonged stress, an established posttraumatic stress disorder model, exhibited persistent mechanical allodynia and anxiety-like behavior, which were accompanied by increased activation of microglia and secretion of pro-inflammatory cytokines in the hippocampus. Correlation analyses showed that hippocampal activation of microglia was significantly correlated with mechanical allodynia and anxiety-like behavior. Our data also showed that both intraperitoneal and intra-hippocampal injection of minocycline suppressed single prolonged stress-induced microglia activation and inflammatory cytokines accumulation in the hippocampus, and attenuated both single prolonged stress-induced mechanical allodynia and anxiety-like behavior. Taken together, the present study suggests that stress-induced microglia activation in the hippocampus may serve as a critical mechanistic link in the comorbid relationship between posttraumatic stress disorder and chronic pain. The novel concept introduces the possibility of cotreating chronic pain and posttraumatic stress disorder. |
format | Online Article Text |
id | pubmed-5117253 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-51172532016-11-28 Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain Sun, Rao Zhang, Zuoxia Lei, Yishan Liu, Yue Lu, Cui’e Rong, Hui Sun, Yu’e Zhang, Wei Ma, Zhengliang Gu, Xiaoping Mol Pain Research Article The high comorbidity rates of posttraumatic stress disorder and chronic pain have been widely reported, but the underlying mechanisms remain unclear. Emerging evidence suggested that an excess of inflammatory immune activities in the hippocampus involved in the progression of both posttraumatic stress disorder and chronic pain. Considering that microglia are substrates underlying the initiation and propagation of the neuroimmune response, we hypothesized that stress-induced activation of hippocampal microglia may contribute to the pathogenesis of posttraumatic stress disorder-pain comorbidity. We showed that rats exposed to single prolonged stress, an established posttraumatic stress disorder model, exhibited persistent mechanical allodynia and anxiety-like behavior, which were accompanied by increased activation of microglia and secretion of pro-inflammatory cytokines in the hippocampus. Correlation analyses showed that hippocampal activation of microglia was significantly correlated with mechanical allodynia and anxiety-like behavior. Our data also showed that both intraperitoneal and intra-hippocampal injection of minocycline suppressed single prolonged stress-induced microglia activation and inflammatory cytokines accumulation in the hippocampus, and attenuated both single prolonged stress-induced mechanical allodynia and anxiety-like behavior. Taken together, the present study suggests that stress-induced microglia activation in the hippocampus may serve as a critical mechanistic link in the comorbid relationship between posttraumatic stress disorder and chronic pain. The novel concept introduces the possibility of cotreating chronic pain and posttraumatic stress disorder. SAGE Publications 2016-11-15 /pmc/articles/PMC5117253/ /pubmed/27852966 http://dx.doi.org/10.1177/1744806916679166 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Research Article Sun, Rao Zhang, Zuoxia Lei, Yishan Liu, Yue Lu, Cui’e Rong, Hui Sun, Yu’e Zhang, Wei Ma, Zhengliang Gu, Xiaoping Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain |
title | Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain |
title_full | Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain |
title_fullStr | Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain |
title_full_unstemmed | Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain |
title_short | Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain |
title_sort | hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117253/ https://www.ncbi.nlm.nih.gov/pubmed/27852966 http://dx.doi.org/10.1177/1744806916679166 |
work_keys_str_mv | AT sunrao hippocampalactivationofmicrogliamayunderliethesharedneurobiologyofcomorbidposttraumaticstressdisorderandchronicpain AT zhangzuoxia hippocampalactivationofmicrogliamayunderliethesharedneurobiologyofcomorbidposttraumaticstressdisorderandchronicpain AT leiyishan hippocampalactivationofmicrogliamayunderliethesharedneurobiologyofcomorbidposttraumaticstressdisorderandchronicpain AT liuyue hippocampalactivationofmicrogliamayunderliethesharedneurobiologyofcomorbidposttraumaticstressdisorderandchronicpain AT lucuie hippocampalactivationofmicrogliamayunderliethesharedneurobiologyofcomorbidposttraumaticstressdisorderandchronicpain AT ronghui hippocampalactivationofmicrogliamayunderliethesharedneurobiologyofcomorbidposttraumaticstressdisorderandchronicpain AT sunyue hippocampalactivationofmicrogliamayunderliethesharedneurobiologyofcomorbidposttraumaticstressdisorderandchronicpain AT zhangwei hippocampalactivationofmicrogliamayunderliethesharedneurobiologyofcomorbidposttraumaticstressdisorderandchronicpain AT mazhengliang hippocampalactivationofmicrogliamayunderliethesharedneurobiologyofcomorbidposttraumaticstressdisorderandchronicpain AT guxiaoping hippocampalactivationofmicrogliamayunderliethesharedneurobiologyofcomorbidposttraumaticstressdisorderandchronicpain |