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From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol

In spite of the global reputation of ethanol as the psychopharmacologically active ingredient of alcoholic drinks, the neurobiological basis of the central effects of ethanol still presents some dark sides due to a number of unanswered questions related to both its precise mechanism of action and it...

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Detalles Bibliográficos
Autores principales: Peana, Alessandra T., Rosas, Michela, Porru, Simona, Acquas, Elio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117487/
https://www.ncbi.nlm.nih.gov/pubmed/27891052
http://dx.doi.org/10.4137/JEN.S25099
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author Peana, Alessandra T.
Rosas, Michela
Porru, Simona
Acquas, Elio
author_facet Peana, Alessandra T.
Rosas, Michela
Porru, Simona
Acquas, Elio
author_sort Peana, Alessandra T.
collection PubMed
description In spite of the global reputation of ethanol as the psychopharmacologically active ingredient of alcoholic drinks, the neurobiological basis of the central effects of ethanol still presents some dark sides due to a number of unanswered questions related to both its precise mechanism of action and its metabolism. Accordingly, ethanol represents the interesting example of a compound whose actions cannot be explained as simply due to the involvement of a single receptor/neurotransmitter, a scenario further complicated by the robust evidence that two main metabolites, acetaldehyde and salsolinol, exert many effects similar to those of their parent compound. The present review recapitulates, in a perspective manner, the major and most recent advances that in the last decades boosted a significant growth in the understanding on the role of ethanol metabolism, in particular, in the neurobiological basis of its central effects.
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spelling pubmed-51174872016-11-26 From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol Peana, Alessandra T. Rosas, Michela Porru, Simona Acquas, Elio J Exp Neurosci Review In spite of the global reputation of ethanol as the psychopharmacologically active ingredient of alcoholic drinks, the neurobiological basis of the central effects of ethanol still presents some dark sides due to a number of unanswered questions related to both its precise mechanism of action and its metabolism. Accordingly, ethanol represents the interesting example of a compound whose actions cannot be explained as simply due to the involvement of a single receptor/neurotransmitter, a scenario further complicated by the robust evidence that two main metabolites, acetaldehyde and salsolinol, exert many effects similar to those of their parent compound. The present review recapitulates, in a perspective manner, the major and most recent advances that in the last decades boosted a significant growth in the understanding on the role of ethanol metabolism, in particular, in the neurobiological basis of its central effects. Libertas Academica 2016-11-20 /pmc/articles/PMC5117487/ /pubmed/27891052 http://dx.doi.org/10.4137/JEN.S25099 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Review
Peana, Alessandra T.
Rosas, Michela
Porru, Simona
Acquas, Elio
From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol
title From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol
title_full From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol
title_fullStr From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol
title_full_unstemmed From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol
title_short From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol
title_sort from ethanol to salsolinol: role of ethanol metabolites in the effects of ethanol
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117487/
https://www.ncbi.nlm.nih.gov/pubmed/27891052
http://dx.doi.org/10.4137/JEN.S25099
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