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From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol
In spite of the global reputation of ethanol as the psychopharmacologically active ingredient of alcoholic drinks, the neurobiological basis of the central effects of ethanol still presents some dark sides due to a number of unanswered questions related to both its precise mechanism of action and it...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117487/ https://www.ncbi.nlm.nih.gov/pubmed/27891052 http://dx.doi.org/10.4137/JEN.S25099 |
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author | Peana, Alessandra T. Rosas, Michela Porru, Simona Acquas, Elio |
author_facet | Peana, Alessandra T. Rosas, Michela Porru, Simona Acquas, Elio |
author_sort | Peana, Alessandra T. |
collection | PubMed |
description | In spite of the global reputation of ethanol as the psychopharmacologically active ingredient of alcoholic drinks, the neurobiological basis of the central effects of ethanol still presents some dark sides due to a number of unanswered questions related to both its precise mechanism of action and its metabolism. Accordingly, ethanol represents the interesting example of a compound whose actions cannot be explained as simply due to the involvement of a single receptor/neurotransmitter, a scenario further complicated by the robust evidence that two main metabolites, acetaldehyde and salsolinol, exert many effects similar to those of their parent compound. The present review recapitulates, in a perspective manner, the major and most recent advances that in the last decades boosted a significant growth in the understanding on the role of ethanol metabolism, in particular, in the neurobiological basis of its central effects. |
format | Online Article Text |
id | pubmed-5117487 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-51174872016-11-26 From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol Peana, Alessandra T. Rosas, Michela Porru, Simona Acquas, Elio J Exp Neurosci Review In spite of the global reputation of ethanol as the psychopharmacologically active ingredient of alcoholic drinks, the neurobiological basis of the central effects of ethanol still presents some dark sides due to a number of unanswered questions related to both its precise mechanism of action and its metabolism. Accordingly, ethanol represents the interesting example of a compound whose actions cannot be explained as simply due to the involvement of a single receptor/neurotransmitter, a scenario further complicated by the robust evidence that two main metabolites, acetaldehyde and salsolinol, exert many effects similar to those of their parent compound. The present review recapitulates, in a perspective manner, the major and most recent advances that in the last decades boosted a significant growth in the understanding on the role of ethanol metabolism, in particular, in the neurobiological basis of its central effects. Libertas Academica 2016-11-20 /pmc/articles/PMC5117487/ /pubmed/27891052 http://dx.doi.org/10.4137/JEN.S25099 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License. |
spellingShingle | Review Peana, Alessandra T. Rosas, Michela Porru, Simona Acquas, Elio From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol |
title | From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol |
title_full | From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol |
title_fullStr | From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol |
title_full_unstemmed | From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol |
title_short | From Ethanol to Salsolinol: Role of Ethanol Metabolites in the Effects of Ethanol |
title_sort | from ethanol to salsolinol: role of ethanol metabolites in the effects of ethanol |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117487/ https://www.ncbi.nlm.nih.gov/pubmed/27891052 http://dx.doi.org/10.4137/JEN.S25099 |
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