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Long term results of PDR brachytherapy for lip cancer

PURPOSE: To evaluate the long time outcome with regard to local tumour control and side effects of a pulsed dose rate (PDR) monobrachytherapy of primary or recurrent cancer of the lip. MATERIAL AND METHODS: Between 1995 and 2007 we treated 43 patients with primary or recurrent clinical T1-T3N0 lip c...

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Autores principales: Johansson, Bengt, Karlsson, Leif, Hardell, Lennart, Persliden, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117532/
https://www.ncbi.nlm.nih.gov/pubmed/27895671
http://dx.doi.org/10.5114/jcb.2011.23199
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author Johansson, Bengt
Karlsson, Leif
Hardell, Lennart
Persliden, Jan
author_facet Johansson, Bengt
Karlsson, Leif
Hardell, Lennart
Persliden, Jan
author_sort Johansson, Bengt
collection PubMed
description PURPOSE: To evaluate the long time outcome with regard to local tumour control and side effects of a pulsed dose rate (PDR) monobrachytherapy of primary or recurrent cancer of the lip. MATERIAL AND METHODS: Between 1995 and 2007 we treated 43 patients with primary or recurrent clinical T1-T3N0 lip cancers. There were 22 T1 patients (51%), 16 T2 (37%) and 5 T3 cases (12%). A median dose of 60 (55-66) Gy was given, depending on the tumour volume. The PDR treatment was delivered with 0.83 Gy/pulse every second hour for 5.5-6.5 days. The patients were followed for a median of 55 (1-158) months. RESULTS: The 2-, 5- and 10-year rates of actuarial local control were 97.6%, 94.5% and 94.5%, overall survival 88.0%, 58.9% and 39.1%, disease free survival 92.7%, 86.4% and 86.4% respectively. The regional control rate was 93%. One patient (2%) developed distant metastases. A dosimetrical analysis showed a mean treated volume of 14.9 (3.0-56.2) cm(3). Long-term side effects were mild and the cosmetic outcome excellent, except for 1 case (2%) of soft tissue necrosis and 1 case (2%) of osteoradionecrosis. CONCLUSIONS: Local outcome is excellent and similar to other published studies of continuous low dose rate (cLDR) brachytherapy.
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spelling pubmed-51175322016-11-28 Long term results of PDR brachytherapy for lip cancer Johansson, Bengt Karlsson, Leif Hardell, Lennart Persliden, Jan J Contemp Brachytherapy Original Article PURPOSE: To evaluate the long time outcome with regard to local tumour control and side effects of a pulsed dose rate (PDR) monobrachytherapy of primary or recurrent cancer of the lip. MATERIAL AND METHODS: Between 1995 and 2007 we treated 43 patients with primary or recurrent clinical T1-T3N0 lip cancers. There were 22 T1 patients (51%), 16 T2 (37%) and 5 T3 cases (12%). A median dose of 60 (55-66) Gy was given, depending on the tumour volume. The PDR treatment was delivered with 0.83 Gy/pulse every second hour for 5.5-6.5 days. The patients were followed for a median of 55 (1-158) months. RESULTS: The 2-, 5- and 10-year rates of actuarial local control were 97.6%, 94.5% and 94.5%, overall survival 88.0%, 58.9% and 39.1%, disease free survival 92.7%, 86.4% and 86.4% respectively. The regional control rate was 93%. One patient (2%) developed distant metastases. A dosimetrical analysis showed a mean treated volume of 14.9 (3.0-56.2) cm(3). Long-term side effects were mild and the cosmetic outcome excellent, except for 1 case (2%) of soft tissue necrosis and 1 case (2%) of osteoradionecrosis. CONCLUSIONS: Local outcome is excellent and similar to other published studies of continuous low dose rate (cLDR) brachytherapy. Termedia Publishing House 2011-07-06 2011-06 /pmc/articles/PMC5117532/ /pubmed/27895671 http://dx.doi.org/10.5114/jcb.2011.23199 Text en Copyright: © 2011 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Article
Johansson, Bengt
Karlsson, Leif
Hardell, Lennart
Persliden, Jan
Long term results of PDR brachytherapy for lip cancer
title Long term results of PDR brachytherapy for lip cancer
title_full Long term results of PDR brachytherapy for lip cancer
title_fullStr Long term results of PDR brachytherapy for lip cancer
title_full_unstemmed Long term results of PDR brachytherapy for lip cancer
title_short Long term results of PDR brachytherapy for lip cancer
title_sort long term results of pdr brachytherapy for lip cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117532/
https://www.ncbi.nlm.nih.gov/pubmed/27895671
http://dx.doi.org/10.5114/jcb.2011.23199
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