The extracellular microscape governs mesenchymal stem cell fate

Each cell forever interacts with its extracellular matrix (ECM); a stem cell relies on this interaction to guide differentiation. The stiffness, nanotopography, protein composition, stress and strain inherent to any given ECM influences stem cell lineage commitment. This interaction is dynamic, mult...

Descripción completa

Detalles Bibliográficos
Autores principales: Hadden, William J., Choi, Yu Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117578/
https://www.ncbi.nlm.nih.gov/pubmed/27895704
http://dx.doi.org/10.1186/s13036-016-0037-0
_version_ 1782468832111099904
author Hadden, William J.
Choi, Yu Suk
author_facet Hadden, William J.
Choi, Yu Suk
author_sort Hadden, William J.
collection PubMed
description Each cell forever interacts with its extracellular matrix (ECM); a stem cell relies on this interaction to guide differentiation. The stiffness, nanotopography, protein composition, stress and strain inherent to any given ECM influences stem cell lineage commitment. This interaction is dynamic, multidimensional and reciprocally evolving through time, and from this concerted exchange the macroscopic tissues that comprise living organisms are formed. Mesenchymal stem cells can give rise to bone, cartilage, tendon and muscle; thus attempts to manipulate their differentiation must heed the physical properties of incredibly complex native microenvironments to realize regenerative goals.
format Online
Article
Text
id pubmed-5117578
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-51175782016-11-28 The extracellular microscape governs mesenchymal stem cell fate Hadden, William J. Choi, Yu Suk J Biol Eng Review Each cell forever interacts with its extracellular matrix (ECM); a stem cell relies on this interaction to guide differentiation. The stiffness, nanotopography, protein composition, stress and strain inherent to any given ECM influences stem cell lineage commitment. This interaction is dynamic, multidimensional and reciprocally evolving through time, and from this concerted exchange the macroscopic tissues that comprise living organisms are formed. Mesenchymal stem cells can give rise to bone, cartilage, tendon and muscle; thus attempts to manipulate their differentiation must heed the physical properties of incredibly complex native microenvironments to realize regenerative goals. BioMed Central 2016-11-21 /pmc/articles/PMC5117578/ /pubmed/27895704 http://dx.doi.org/10.1186/s13036-016-0037-0 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Hadden, William J.
Choi, Yu Suk
The extracellular microscape governs mesenchymal stem cell fate
title The extracellular microscape governs mesenchymal stem cell fate
title_full The extracellular microscape governs mesenchymal stem cell fate
title_fullStr The extracellular microscape governs mesenchymal stem cell fate
title_full_unstemmed The extracellular microscape governs mesenchymal stem cell fate
title_short The extracellular microscape governs mesenchymal stem cell fate
title_sort extracellular microscape governs mesenchymal stem cell fate
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117578/
https://www.ncbi.nlm.nih.gov/pubmed/27895704
http://dx.doi.org/10.1186/s13036-016-0037-0
work_keys_str_mv AT haddenwilliamj theextracellularmicroscapegovernsmesenchymalstemcellfate
AT choiyusuk theextracellularmicroscapegovernsmesenchymalstemcellfate
AT haddenwilliamj extracellularmicroscapegovernsmesenchymalstemcellfate
AT choiyusuk extracellularmicroscapegovernsmesenchymalstemcellfate

Ejemplares similares