Occurrence of Diverse Antimicrobial Resistance Determinants in Genetically Unrelated Biocide Tolerant Klebsiella pneumoniae

Nosocomial infections due to Klebsiella pneumoniae is a significant problem in health care settings worldwide. In this study, we examined the antimicrobial susceptibility, genetic profiles and mechanisms of antibiotic resistance in K. pneumoniae isolates of Indian origin. To our knowledge this is th...

Descripción completa

Detalles Bibliográficos
Autores principales: Mondal, Amitabha, Venkataramaiah, Manjunath, Rajamohan, Govindan, Srinivasan, Vijaya Bharathi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117710/
https://www.ncbi.nlm.nih.gov/pubmed/27870879
http://dx.doi.org/10.1371/journal.pone.0166730
_version_ 1782468850830278656
author Mondal, Amitabha
Venkataramaiah, Manjunath
Rajamohan, Govindan
Srinivasan, Vijaya Bharathi
author_facet Mondal, Amitabha
Venkataramaiah, Manjunath
Rajamohan, Govindan
Srinivasan, Vijaya Bharathi
author_sort Mondal, Amitabha
collection PubMed
description Nosocomial infections due to Klebsiella pneumoniae is a significant problem in health care settings worldwide. In this study, we examined the antimicrobial susceptibility, genetic profiles and mechanisms of antibiotic resistance in K. pneumoniae isolates of Indian origin. To our knowledge this is the first report demonstrating the high prevalence of β-lactamases, aminoglycoside modifying enzymes, quinolone resistance genes besides demonstrating the involvement of active efflux in K. pneumoniae Indian isolates. This study has enabled us to correlate the phenotypic and genotypic characteristics in K. pneumoniae, providing an important base for continued monitoring and epidemiological studies of this emerging nosocomial pathogen in Indian hospitals.
format Online
Article
Text
id pubmed-5117710
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-51177102016-12-15 Occurrence of Diverse Antimicrobial Resistance Determinants in Genetically Unrelated Biocide Tolerant Klebsiella pneumoniae Mondal, Amitabha Venkataramaiah, Manjunath Rajamohan, Govindan Srinivasan, Vijaya Bharathi PLoS One Research Article Nosocomial infections due to Klebsiella pneumoniae is a significant problem in health care settings worldwide. In this study, we examined the antimicrobial susceptibility, genetic profiles and mechanisms of antibiotic resistance in K. pneumoniae isolates of Indian origin. To our knowledge this is the first report demonstrating the high prevalence of β-lactamases, aminoglycoside modifying enzymes, quinolone resistance genes besides demonstrating the involvement of active efflux in K. pneumoniae Indian isolates. This study has enabled us to correlate the phenotypic and genotypic characteristics in K. pneumoniae, providing an important base for continued monitoring and epidemiological studies of this emerging nosocomial pathogen in Indian hospitals. Public Library of Science 2016-11-21 /pmc/articles/PMC5117710/ /pubmed/27870879 http://dx.doi.org/10.1371/journal.pone.0166730 Text en © 2016 Mondal et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mondal, Amitabha
Venkataramaiah, Manjunath
Rajamohan, Govindan
Srinivasan, Vijaya Bharathi
Occurrence of Diverse Antimicrobial Resistance Determinants in Genetically Unrelated Biocide Tolerant Klebsiella pneumoniae
title Occurrence of Diverse Antimicrobial Resistance Determinants in Genetically Unrelated Biocide Tolerant Klebsiella pneumoniae
title_full Occurrence of Diverse Antimicrobial Resistance Determinants in Genetically Unrelated Biocide Tolerant Klebsiella pneumoniae
title_fullStr Occurrence of Diverse Antimicrobial Resistance Determinants in Genetically Unrelated Biocide Tolerant Klebsiella pneumoniae
title_full_unstemmed Occurrence of Diverse Antimicrobial Resistance Determinants in Genetically Unrelated Biocide Tolerant Klebsiella pneumoniae
title_short Occurrence of Diverse Antimicrobial Resistance Determinants in Genetically Unrelated Biocide Tolerant Klebsiella pneumoniae
title_sort occurrence of diverse antimicrobial resistance determinants in genetically unrelated biocide tolerant klebsiella pneumoniae
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117710/
https://www.ncbi.nlm.nih.gov/pubmed/27870879
http://dx.doi.org/10.1371/journal.pone.0166730
work_keys_str_mv AT mondalamitabha occurrenceofdiverseantimicrobialresistancedeterminantsingeneticallyunrelatedbiocidetolerantklebsiellapneumoniae
AT venkataramaiahmanjunath occurrenceofdiverseantimicrobialresistancedeterminantsingeneticallyunrelatedbiocidetolerantklebsiellapneumoniae
AT rajamohangovindan occurrenceofdiverseantimicrobialresistancedeterminantsingeneticallyunrelatedbiocidetolerantklebsiellapneumoniae
AT srinivasanvijayabharathi occurrenceofdiverseantimicrobialresistancedeterminantsingeneticallyunrelatedbiocidetolerantklebsiellapneumoniae

Ejemplares similares