Engineering Archeal Surrogate Systems for the Development of Protein–Protein Interaction Inhibitors against Human RAD51

Protein–protein interactions (PPIs) are increasingly important targets for drug discovery. Efficient fragment-based drug discovery approaches to tackle PPIs are often stymied by difficulties in the production of stable, unliganded target proteins. Here, we report an approach that exploits protein en...

Descripción completa

Detalles Bibliográficos
Autores principales: Moschetti, Tommaso, Sharpe, Timothy, Fischer, Gerhard, Marsh, May E., Ng, Hong Kin, Morgan, Matthew, Scott, Duncan E., Blundell, Tom L., R. Venkitaraman, Ashok, Skidmore, John, Abell, Chris, Hyvönen, Marko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117717/
https://www.ncbi.nlm.nih.gov/pubmed/27725183
http://dx.doi.org/10.1016/j.jmb.2016.10.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117717/
https://www.ncbi.nlm.nih.gov/pubmed/27725183
http://dx.doi.org/10.1016/j.jmb.2016.10.009

Ejemplares similares