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ATP Hydrolysis Induced Conformational Changes in the Vitamin B(12) Transporter BtuCD Revealed by MD Simulations
ATP binding cassette (ABC) transporters utilize the energy of ATP hydrolysis to uni-directionally transport substrates across cell membrane. ATP hydrolysis occurs at the nucleotide-binding domain (NBD) dimer interface of ABC transporters, whereas substrate translocation takes place at the translocat...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117765/ https://www.ncbi.nlm.nih.gov/pubmed/27870912 http://dx.doi.org/10.1371/journal.pone.0166980 |