Effects of resveratrol on P-glycoprotein and cytochrome P450 3A in vitro and on pharmacokinetics of oral saquinavir in rats

BACKGROUND: The intestinal cytochrome P450 3A (CYP 3A) and P-glycoprotein (P-gp) present a barrier to the oral absorption of saquinavir (SQV). Resveratrol (RESV) has been indicated to have modulatory effects on P-gp and CYP 3A. Therefore, this study was to investigate the effects of RESV on P-gp and...

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Detalles Bibliográficos
Autores principales: Li, Jiapeng, Liu, Yang, Zhang, Jingru, Yu, Xiaotong, Wang, Xiaoling, Zhao, Libo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117956/
https://www.ncbi.nlm.nih.gov/pubmed/27895462
http://dx.doi.org/10.2147/DDDT.S118723

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