Cargando…

STAT3 as a potential therapeutic target in ALDH(+) and CD44(+)/CD24(+) stem cell-like pancreatic cancer cells

Persistent activation of signal transducers and activators of transcription 3 (STAT3) is commonly detected in many types of cancer including pancreatic cancer. Whether STAT3 is activated in stem cell-like pancreatic cancer cells and the effect of STAT3 inhibition, is still unknown. Flow cytometry wa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Li, Jou, David, Wang, Yina, Ma, Haiyan, Liu, Tianshu, Fuchs, James, Li, Pui-Kai, Lü, Jiagao, Li, Chenglong, Lin, Jiayuh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118001/ https://www.ncbi.nlm.nih.gov/pubmed/27748818 http://dx.doi.org/10.3892/ijo.2016.3728

Ejemplares similares

Evaluation of STAT3 Signaling in ALDH+ and ALDH+/CD44+/CD24− Subpopulations of Breast Cancer Cells
por: Lin, Li, et al.
Publicado: (2013)

A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells
por: Zhao, Chongqiang, et al.
Publicado: (2016)

Growth-suppressive activity of raloxifene on liver cancer cells by targeting IL-6/GP130 signaling
por: Wang, Yina, et al.
Publicado: (2017)

Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis
por: Li, Wenzhe, et al.
Publicado: (2017)

Author Correction: Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis
por: Li, Wenzhe, et al.
Publicado: (2018)

Cancer stem cell markers ALDH1 and CD44+/CD24– phenotype and their prognosis impact in invasive ductal carcinoma
por: Rabinovich, Iris, et al.
Publicado: (2018)

A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells
por: Lin, Li, et al.
Publicado: (2010)

The Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Induces Apoptosis in Medulloblastoma and Glioblastoma Cells
por: Ball, Sarah, et al.
Publicado: (2011)

Expression of Androgen Receptor and Cancer Stem Cell Markers (CD44(+)/CD24(−) and ALDH1(+)): Prognostic Implications in Invasive Breast Cancer()()
por: Riaz, Nazia, et al.
Publicado: (2018)

XZH-5 Inhibits STAT3 Phosphorylation and Enhances the Cytotoxicity of Chemotherapeutic Drugs in Human Breast and Pancreatic Cancer Cells
por: Liu, Aiguo, et al.
Publicado: (2012)

Downregulation of CD44 reduces doxorubicin resistance of CD44(+)CD24(−) breast cancer cells
por: Van Phuc, Pham, et al.
Publicado: (2011)

Reliability of CD44, CD24, and ALDH1A1 immunohistochemical staining: Pathologist assessment compared to quantitative image analysis
por: Yaghjyan, Lusine, et al.
Publicado: (2022)

Combination of Cancer Stem Cell Markers CD44 and CD24 Is Superior to ALDH1 as a Prognostic Indicator in Breast Cancer Patients with Distant Metastases
por: Horimoto, Yoshiya, et al.
Publicado: (2016)

STAT3 mediates resistance of CD44(+)CD24(−/low) breast cancer stem cells to tamoxifen in vitro
por: Wang, Xiaoyan, et al.
Publicado: (2012)

Alleviation of Inflammation and Oxidative Stress in Pressure Overload-Induced Cardiac Remodeling and Heart Failure via IL-6/STAT3 Inhibition by Raloxifene
por: Huo, Shengqi, et al.
Publicado: (2021)

Lung cancer tumorigenicity and drug resistance are maintained through ALDH(hi)CD44(hi) tumor initiating cells
por: Liu, Jing, et al.
Publicado: (2013)

ALDH1+ stem cells demonstrate more stem cell-like characteristics than CD44(+)/CD24(–/low) stem cells in different molecular subtypes of breast cancer
por: Chen, Jie, et al.
Publicado: (2020)

Expression and Clinical Significance of Cancer Stem Cell Markers CD24, CD44, and CD133 in Pancreatic Ductal Adenocarcinoma and Chronic Pancreatitis
por: Durko, L., et al.
Publicado: (2017)

CD44 and CD24 coordinate the reprogramming of nasopharyngeal carcinoma cells towards a cancer stem cell phenotype through STAT3 activation
por: Shen, Yao-An, et al.
Publicado: (2016)

Corrigendum to “Expression and Clinical Significance of Cancer Stem Cell Markers CD24, CD44, and CD133 in Pancreatic Ductal Adenocarcinoma and Chronic Pancreatitis”
por: Durko, L., et al.
Publicado: (2017)

Cholangiocarcinoma cells secrete soluble factors that activate Jak/STAT signal transduction and promote MDSC expansion
por: Yang, Jennifer, et al.
Publicado: (2014)

Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells
por: Zhao, Chengguang, et al.
Publicado: (2015)

CD44v/CD44s expression patterns are associated with the survival of pancreatic carcinoma patients
por: Li, Zhonghu, et al.
Publicado: (2014)

ALDH/CD44 identifies uniquely tumorigenic cancer stem cells in salivary gland mucoepidermoid carcinomas
por: Adams, April, et al.
Publicado: (2015)

Dynamic regulation of CD24 and the invasive, CD44(pos)CD24(neg )phenotype in breast cancer cell lines
por: Meyer, Matthew J, et al.
Publicado: (2009)

Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity
por: Jaggupilli, Appalaraju, et al.
Publicado: (2012)

Immunodetection of cells with a CD44+/CD24- phenotype in canine mammary neoplasms
por: Magalhães, Geórgia Modé, et al.
Publicado: (2013)

Bazedoxifene exhibits growth suppressive activity by targeting interleukin‐6/glycoprotein 130/signal transducer and activator of transcription 3 signaling in hepatocellular carcinoma
por: Ma, Haiyan, et al.
Publicado: (2019)

Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer
por: Lugli, A, et al.
Publicado: (2010)

Expression of Smo in pancreatic cancer CD44(+)CD24(+)cells and construction of a lentiviral expression vector to silence Smo
por: Cong, Peng, et al.
Publicado: (2018)

Prognostic Significance of TWIST1, CD24, CD44, and ALDH1 Transcript Quantification in EpCAM-Positive Circulating Tumor Cells from Early Stage Breast Cancer Patients
por: Strati, Areti, et al.
Publicado: (2019)

CD44(+)/CD24(- )breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis
por: Sheridan, Carol, et al.
Publicado: (2006)

Prognostic Value of Cancer Stem Cell Markers CD44 and ALDH1/2 in Gastric Cancer Cases
por: Senel, Fatma, et al.
Publicado: (2017)

Knockdown of ALDH1A3 reduces breast cancer stem cell marker CD44 via the miR-7-TGFBR2-Smad3-CD44 regulatory axis
por: Pan, Meng, et al.
Publicado: (2021)

Cobalt ferrite nanoparticle for the elimination of CD133+CD44(+) and CD44(+)CD24(−), in breast and skin cancer stem cells, using non-ionizing treatments
por: Khalili Najafabad, Bahareh, et al.
Publicado: (2023)

In Situ Identification of CD44+/CD24− Cancer Cells in Primary Human Breast Carcinomas
por: Perrone, Giuseppe, et al.
Publicado: (2012)

Association of human breast cancer CD44(-)/CD24(-) cells with delayed distant metastasis
por: Qiao, Xinbo, et al.
Publicado: (2021)

Acetylation and activation of STAT3 mediated by nuclear translocation of CD44
por: Lee, Jia-Lin, et al.
Publicado: (2009)

LLL12, a novel small inhibitor targeting STAT3 for hepatocellular carcinoma therapy
por: Zuo, Mingxin, et al.
Publicado: (2015)

LLL12B, a Novel Small-Molecule STAT3 Inhibitor, Induces Apoptosis and Suppresses Cell Migration and Tumor Growth in Triple-Negative Breast Cancer Cells
por: Pan, Li, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_g1mvapmq9st0m16luf1b119dhs