The Dynamics of T and B Cells in Lymph Node during Chronic HIV Infection: TFH and HIV, Unhappy Dance Partners?

Although the dynamics of germinal center (GC) formation, follicular helper T (TFH) cell recruitment to B cell follicles within lymphoid organs, and changes of lymphoid tissue architecture in HIV/SIV infection have been documented, the underlying immunopathology remains unclear. Here, we summarize wh...

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Autores principales: Hong, Jung Joo, Chang, Kyu-Tae, Villinger, Francois
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118424/
https://www.ncbi.nlm.nih.gov/pubmed/27920778
http://dx.doi.org/10.3389/fimmu.2016.00522
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author Hong, Jung Joo
Chang, Kyu-Tae
Villinger, Francois
author_facet Hong, Jung Joo
Chang, Kyu-Tae
Villinger, Francois
author_sort Hong, Jung Joo
collection PubMed
description Although the dynamics of germinal center (GC) formation, follicular helper T (TFH) cell recruitment to B cell follicles within lymphoid organs, and changes of lymphoid tissue architecture in HIV/SIV infection have been documented, the underlying immunopathology remains unclear. Here, we summarize what is known regarding the kinetics of TFH cells and GC B cells during the course of infection as well as the potential immunopathological features associated with structural changes in the lymphoid compartment. This review also explores the implications of cell dynamics in the formation and maintenance of viral reservoirs in hyperplastic follicles of secondary lymphoid organs before and after viral suppressive antiretroviral therapy.
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spelling pubmed-51184242016-12-05 The Dynamics of T and B Cells in Lymph Node during Chronic HIV Infection: TFH and HIV, Unhappy Dance Partners? Hong, Jung Joo Chang, Kyu-Tae Villinger, Francois Front Immunol Immunology Although the dynamics of germinal center (GC) formation, follicular helper T (TFH) cell recruitment to B cell follicles within lymphoid organs, and changes of lymphoid tissue architecture in HIV/SIV infection have been documented, the underlying immunopathology remains unclear. Here, we summarize what is known regarding the kinetics of TFH cells and GC B cells during the course of infection as well as the potential immunopathological features associated with structural changes in the lymphoid compartment. This review also explores the implications of cell dynamics in the formation and maintenance of viral reservoirs in hyperplastic follicles of secondary lymphoid organs before and after viral suppressive antiretroviral therapy. Frontiers Media S.A. 2016-11-22 /pmc/articles/PMC5118424/ /pubmed/27920778 http://dx.doi.org/10.3389/fimmu.2016.00522 Text en Copyright © 2016 Hong, Chang and Villinger. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Hong, Jung Joo
Chang, Kyu-Tae
Villinger, Francois
The Dynamics of T and B Cells in Lymph Node during Chronic HIV Infection: TFH and HIV, Unhappy Dance Partners?
title The Dynamics of T and B Cells in Lymph Node during Chronic HIV Infection: TFH and HIV, Unhappy Dance Partners?
title_full The Dynamics of T and B Cells in Lymph Node during Chronic HIV Infection: TFH and HIV, Unhappy Dance Partners?
title_fullStr The Dynamics of T and B Cells in Lymph Node during Chronic HIV Infection: TFH and HIV, Unhappy Dance Partners?
title_full_unstemmed The Dynamics of T and B Cells in Lymph Node during Chronic HIV Infection: TFH and HIV, Unhappy Dance Partners?
title_short The Dynamics of T and B Cells in Lymph Node during Chronic HIV Infection: TFH and HIV, Unhappy Dance Partners?
title_sort dynamics of t and b cells in lymph node during chronic hiv infection: tfh and hiv, unhappy dance partners?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118424/
https://www.ncbi.nlm.nih.gov/pubmed/27920778
http://dx.doi.org/10.3389/fimmu.2016.00522
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