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Myeloproliferative Disease: An Unusual Cause of Raynaud's Phenomenon and Digital Ischaemia
We describe a 59-year-old female who presented with ischaemic digits, preceded by a 6-month history of Raynaud's phenomenon affecting her fingers and toes. There were no clinical or laboratory features of primary vasculitis or connective tissue disease, Doppler imaging was normal, and bloods we...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118510/ https://www.ncbi.nlm.nih.gov/pubmed/27895669 http://dx.doi.org/10.1155/2016/9675171 |
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author | Beynon, Celia Huws, Gwenan Lawson, Tom |
author_facet | Beynon, Celia Huws, Gwenan Lawson, Tom |
author_sort | Beynon, Celia |
collection | PubMed |
description | We describe a 59-year-old female who presented with ischaemic digits, preceded by a 6-month history of Raynaud's phenomenon affecting her fingers and toes. There were no clinical or laboratory features of primary vasculitis or connective tissue disease, Doppler imaging was normal, and bloods were unremarkable aside from a platelet count of 786 × 109/L (150–400) and white cells of 16 × 109/L (4–11). In view of the thrombocytosis a JAK2 mutation assay was requested which confirmed a JAK2 V617F mutation, suggesting essential thrombocytosis (ET) as the cause. She received treatment with hydroxycarbamide which normalised her platelet count and led to a complete resolution of her Raynaud's symptoms. Raynaud's phenomenon is a rare manifestation of ET. Myeloproliferative disorders such as ET should be considered in the differential diagnosis of Raynaud's phenomenon and vasculitis. |
format | Online Article Text |
id | pubmed-5118510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-51185102016-11-28 Myeloproliferative Disease: An Unusual Cause of Raynaud's Phenomenon and Digital Ischaemia Beynon, Celia Huws, Gwenan Lawson, Tom Case Rep Med Case Report We describe a 59-year-old female who presented with ischaemic digits, preceded by a 6-month history of Raynaud's phenomenon affecting her fingers and toes. There were no clinical or laboratory features of primary vasculitis or connective tissue disease, Doppler imaging was normal, and bloods were unremarkable aside from a platelet count of 786 × 109/L (150–400) and white cells of 16 × 109/L (4–11). In view of the thrombocytosis a JAK2 mutation assay was requested which confirmed a JAK2 V617F mutation, suggesting essential thrombocytosis (ET) as the cause. She received treatment with hydroxycarbamide which normalised her platelet count and led to a complete resolution of her Raynaud's symptoms. Raynaud's phenomenon is a rare manifestation of ET. Myeloproliferative disorders such as ET should be considered in the differential diagnosis of Raynaud's phenomenon and vasculitis. Hindawi Publishing Corporation 2016 2016-11-08 /pmc/articles/PMC5118510/ /pubmed/27895669 http://dx.doi.org/10.1155/2016/9675171 Text en Copyright © 2016 Celia Beynon et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Beynon, Celia Huws, Gwenan Lawson, Tom Myeloproliferative Disease: An Unusual Cause of Raynaud's Phenomenon and Digital Ischaemia |
title | Myeloproliferative Disease: An Unusual Cause of Raynaud's Phenomenon and Digital Ischaemia |
title_full | Myeloproliferative Disease: An Unusual Cause of Raynaud's Phenomenon and Digital Ischaemia |
title_fullStr | Myeloproliferative Disease: An Unusual Cause of Raynaud's Phenomenon and Digital Ischaemia |
title_full_unstemmed | Myeloproliferative Disease: An Unusual Cause of Raynaud's Phenomenon and Digital Ischaemia |
title_short | Myeloproliferative Disease: An Unusual Cause of Raynaud's Phenomenon and Digital Ischaemia |
title_sort | myeloproliferative disease: an unusual cause of raynaud's phenomenon and digital ischaemia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118510/ https://www.ncbi.nlm.nih.gov/pubmed/27895669 http://dx.doi.org/10.1155/2016/9675171 |
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