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Abuse Potential and Pharmacodynamic Characteristics of Oral and Intranasal Eluxadoline, a Mixed μ- and κ-Opioid Receptor Agonist and δ-Opioid Receptor Antagonist

Drugs with μ-opioid receptor (OR) activity can be associated with abuse and misuse. The peripherally acting mixed μ-OR and κ-OR agonist and δ-OR antagonist eluxadoline is approved in the United States for the treatment of irritable bowel syndrome with diarrhea. In two separate crossover studies, we...

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Detalles Bibliográficos
Autores principales:	Levy-Cooperman, N., McIntyre, G., Bonifacio, L., McDonnell, M., Davenport, J. M., Covington, P. S., Dove, L. S., Sellers, E. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2016
Materias:	Behavioral Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118645/ https://www.ncbi.nlm.nih.gov/pubmed/27647873 http://dx.doi.org/10.1124/jpet.116.236547

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