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Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis

Epstein-Barr virus (EBV) has been associated with several types of human cancers. In the host, EBV can establish two alternative modes of life cycle, known as latent or lytic and the switch from latency to the lytic cycle is known as EBV reactivation. Although EBV in cancer cells is found mostly in...

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Detalles Bibliográficos
Autores principales: Li, Hongde, Liu, Sufang, Hu, Jianmin, Luo, Xiangjian, Li, Namei, M.Bode, Ann, Cao, Ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118777/
https://www.ncbi.nlm.nih.gov/pubmed/27877083
http://dx.doi.org/10.7150/ijbs.16564
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author Li, Hongde
Liu, Sufang
Hu, Jianmin
Luo, Xiangjian
Li, Namei
M.Bode, Ann
Cao, Ya
author_facet Li, Hongde
Liu, Sufang
Hu, Jianmin
Luo, Xiangjian
Li, Namei
M.Bode, Ann
Cao, Ya
author_sort Li, Hongde
collection PubMed
description Epstein-Barr virus (EBV) has been associated with several types of human cancers. In the host, EBV can establish two alternative modes of life cycle, known as latent or lytic and the switch from latency to the lytic cycle is known as EBV reactivation. Although EBV in cancer cells is found mostly in latency, a small number of lytically-infected cells promote carcinogenesis through the release of growth factors and oncogenic cytokines. This review focuses on the mechanisms by which EBV reactivation is controlled by cellular and viral factors, and discusses how EBV lytic infection contributes to human malignancies.
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spelling pubmed-51187772016-11-22 Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis Li, Hongde Liu, Sufang Hu, Jianmin Luo, Xiangjian Li, Namei M.Bode, Ann Cao, Ya Int J Biol Sci Review Epstein-Barr virus (EBV) has been associated with several types of human cancers. In the host, EBV can establish two alternative modes of life cycle, known as latent or lytic and the switch from latency to the lytic cycle is known as EBV reactivation. Although EBV in cancer cells is found mostly in latency, a small number of lytically-infected cells promote carcinogenesis through the release of growth factors and oncogenic cytokines. This review focuses on the mechanisms by which EBV reactivation is controlled by cellular and viral factors, and discusses how EBV lytic infection contributes to human malignancies. Ivyspring International Publisher 2016-10-18 /pmc/articles/PMC5118777/ /pubmed/27877083 http://dx.doi.org/10.7150/ijbs.16564 Text en © Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See http://ivyspring.com/terms for terms and conditions.
spellingShingle Review
Li, Hongde
Liu, Sufang
Hu, Jianmin
Luo, Xiangjian
Li, Namei
M.Bode, Ann
Cao, Ya
Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis
title Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis
title_full Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis
title_fullStr Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis
title_full_unstemmed Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis
title_short Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis
title_sort epstein-barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118777/
https://www.ncbi.nlm.nih.gov/pubmed/27877083
http://dx.doi.org/10.7150/ijbs.16564
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