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Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis
Epstein-Barr virus (EBV) has been associated with several types of human cancers. In the host, EBV can establish two alternative modes of life cycle, known as latent or lytic and the switch from latency to the lytic cycle is known as EBV reactivation. Although EBV in cancer cells is found mostly in...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118777/ https://www.ncbi.nlm.nih.gov/pubmed/27877083 http://dx.doi.org/10.7150/ijbs.16564 |
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author | Li, Hongde Liu, Sufang Hu, Jianmin Luo, Xiangjian Li, Namei M.Bode, Ann Cao, Ya |
author_facet | Li, Hongde Liu, Sufang Hu, Jianmin Luo, Xiangjian Li, Namei M.Bode, Ann Cao, Ya |
author_sort | Li, Hongde |
collection | PubMed |
description | Epstein-Barr virus (EBV) has been associated with several types of human cancers. In the host, EBV can establish two alternative modes of life cycle, known as latent or lytic and the switch from latency to the lytic cycle is known as EBV reactivation. Although EBV in cancer cells is found mostly in latency, a small number of lytically-infected cells promote carcinogenesis through the release of growth factors and oncogenic cytokines. This review focuses on the mechanisms by which EBV reactivation is controlled by cellular and viral factors, and discusses how EBV lytic infection contributes to human malignancies. |
format | Online Article Text |
id | pubmed-5118777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-51187772016-11-22 Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis Li, Hongde Liu, Sufang Hu, Jianmin Luo, Xiangjian Li, Namei M.Bode, Ann Cao, Ya Int J Biol Sci Review Epstein-Barr virus (EBV) has been associated with several types of human cancers. In the host, EBV can establish two alternative modes of life cycle, known as latent or lytic and the switch from latency to the lytic cycle is known as EBV reactivation. Although EBV in cancer cells is found mostly in latency, a small number of lytically-infected cells promote carcinogenesis through the release of growth factors and oncogenic cytokines. This review focuses on the mechanisms by which EBV reactivation is controlled by cellular and viral factors, and discusses how EBV lytic infection contributes to human malignancies. Ivyspring International Publisher 2016-10-18 /pmc/articles/PMC5118777/ /pubmed/27877083 http://dx.doi.org/10.7150/ijbs.16564 Text en © Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See http://ivyspring.com/terms for terms and conditions. |
spellingShingle | Review Li, Hongde Liu, Sufang Hu, Jianmin Luo, Xiangjian Li, Namei M.Bode, Ann Cao, Ya Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis |
title | Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis |
title_full | Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis |
title_fullStr | Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis |
title_full_unstemmed | Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis |
title_short | Epstein-Barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis |
title_sort | epstein-barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118777/ https://www.ncbi.nlm.nih.gov/pubmed/27877083 http://dx.doi.org/10.7150/ijbs.16564 |
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