In-depth comparison of somatic point mutation callers based on different tumor next-generation sequencing depth data

Four popular somatic single nucleotide variant (SNV) calling methods (Varscan, SomaticSniper, Strelka and MuTect2) were carefully evaluated on the real whole exome sequencing (WES, depth of ~50X) and ultra-deep targeted sequencing (UDT-Seq, depth of ~370X) data. The four tools returned poor consensu...

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Detalles Bibliográficos
Autores principales: Cai, Lei, Yuan, Wei, Zhang, Zhou, He, Lin, Chou, Kuo-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118795/
https://www.ncbi.nlm.nih.gov/pubmed/27874022
http://dx.doi.org/10.1038/srep36540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118795/
https://www.ncbi.nlm.nih.gov/pubmed/27874022
http://dx.doi.org/10.1038/srep36540

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