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Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Stomach

Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) is a tumor of small round cells arising in skeletal tissues. These tumors rarely arise in the stomach. We present a 31-year-old healthy female patient who was admitted to our surgical ward due to upper gastrointestinal hemorrhage. Upper endosco...

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Autores principales: Khuri, Safi, Gilshtein, Hayim, Sayidaa, Sa'd, Bishara, Bishara, Kluger, Yoram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118824/
https://www.ncbi.nlm.nih.gov/pubmed/27920700
http://dx.doi.org/10.1159/000449126
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author Khuri, Safi
Gilshtein, Hayim
Sayidaa, Sa'd
Bishara, Bishara
Kluger, Yoram
author_facet Khuri, Safi
Gilshtein, Hayim
Sayidaa, Sa'd
Bishara, Bishara
Kluger, Yoram
author_sort Khuri, Safi
collection PubMed
description Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) is a tumor of small round cells arising in skeletal tissues. These tumors rarely arise in the stomach. We present a 31-year-old healthy female patient who was admitted to our surgical ward due to upper gastrointestinal hemorrhage. Upper endoscopy revealed a large ulcerated bleeding mass originating from the lesser curvature. Biopsy revealed tumor cell immunoreactivity positive for CD99, vimentin, and Ki67 (an index of proliferation). These findings were compatible with gastric ES/PNET. The fluorescence in situ hybridization analysis result for the EWSR1 gene rearrangement (11: 22 translocation) was positive. The patient refused neoadjuvant treatment and thus underwent an operation during which a mass at the lesser curvature of the stomach was found. The mass was adhering to the pancreatic tail and to the mesentery of the transverse and descending colon. Total gastrectomy, distal pancreatectomy, splenectomy, and left adrenalectomy were done. The patient refused adjuvant treatment. She is free of disease 3 years after surgery.
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spelling pubmed-51188242016-12-05 Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Stomach Khuri, Safi Gilshtein, Hayim Sayidaa, Sa'd Bishara, Bishara Kluger, Yoram Case Rep Oncol Case Report Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) is a tumor of small round cells arising in skeletal tissues. These tumors rarely arise in the stomach. We present a 31-year-old healthy female patient who was admitted to our surgical ward due to upper gastrointestinal hemorrhage. Upper endoscopy revealed a large ulcerated bleeding mass originating from the lesser curvature. Biopsy revealed tumor cell immunoreactivity positive for CD99, vimentin, and Ki67 (an index of proliferation). These findings were compatible with gastric ES/PNET. The fluorescence in situ hybridization analysis result for the EWSR1 gene rearrangement (11: 22 translocation) was positive. The patient refused neoadjuvant treatment and thus underwent an operation during which a mass at the lesser curvature of the stomach was found. The mass was adhering to the pancreatic tail and to the mesentery of the transverse and descending colon. Total gastrectomy, distal pancreatectomy, splenectomy, and left adrenalectomy were done. The patient refused adjuvant treatment. She is free of disease 3 years after surgery. S. Karger AG 2016-11-01 /pmc/articles/PMC5118824/ /pubmed/27920700 http://dx.doi.org/10.1159/000449126 Text en Copyright © 2016 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Khuri, Safi
Gilshtein, Hayim
Sayidaa, Sa'd
Bishara, Bishara
Kluger, Yoram
Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Stomach
title Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Stomach
title_full Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Stomach
title_fullStr Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Stomach
title_full_unstemmed Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Stomach
title_short Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Stomach
title_sort primary ewing sarcoma/primitive neuroectodermal tumor of the stomach
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118824/
https://www.ncbi.nlm.nih.gov/pubmed/27920700
http://dx.doi.org/10.1159/000449126
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