Cargando…

Evaluation of hepatitis C virus intrafamilial transmission among families with one index case, a pilot study from Fars province, Iran

AIM: Our aim was to survey the rate and risk factors for Hepatitis C virus interfamilial transmission among families with one index case. BACKGROUND: The role of intrafamilial transmission in Hepatitis C virus epidemiology is still debated. PATIENTS AND METHODS: A cross-sectional study was conducted...

Descripción completa

Detalles Bibliográficos
Autores principales: Lankarani, Kamran B., Ardebili, Maryam, Sepehrimanesh, Masood, Nejabat, Maryam, Hemmati Rad, Mohammad Amir, Hosseini, Seyed Younes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118849/
https://www.ncbi.nlm.nih.gov/pubmed/27895850
_version_ 1782469005288669184
author Lankarani, Kamran B.
Ardebili, Maryam
Sepehrimanesh, Masood
Nejabat, Maryam
Hemmati Rad, Mohammad Amir
Hosseini, Seyed Younes
author_facet Lankarani, Kamran B.
Ardebili, Maryam
Sepehrimanesh, Masood
Nejabat, Maryam
Hemmati Rad, Mohammad Amir
Hosseini, Seyed Younes
author_sort Lankarani, Kamran B.
collection PubMed
description AIM: Our aim was to survey the rate and risk factors for Hepatitis C virus interfamilial transmission among families with one index case. BACKGROUND: The role of intrafamilial transmission in Hepatitis C virus epidemiology is still debated. PATIENTS AND METHODS: A cross-sectional study was conducted on 34 families (236 members) of HCV infected patients from Fars province, spring to summer 2013. All subjects were first evaluated for the risk factors of exposure and then their serum was checked for the presence of HCV antibody and the genome, using ELISA and PCR. The genotype of all PCR positive cases was also determined by a commercial assay. Two independent sample t test and Chi-Square test were used to compare groups together. RESULTS: In 18 out of 34 families, HCV antibody was detected (52.9%) in new members. Among them, HCV transmission in 11 families (32%) was also confirmed by PCR. Having a history of intravenous drug abuse (P=0.006) and incarceration (P=0.01) showed to be important risk factors for interfamilial transmission. Hence, blade/needle sharing (P=0.016) just following molecular assay and sex (P=036) only in the serologic analysis were also determined as significant risk factors. Furthermore, based on serologic results, medium socioeconomic state was further associated with this manner of transmission (P=0.019 and P=0.328). Interestingly, among relatives, 13 cases were brothers while just 5 cases were couples. The genotypes 3a and 1a were more prevalent among the population. CONCLUSION: In conclusion, our finding highlighted a noticeable role of interfamilial transmission for HCV spread and supports the significant role of close relatives, especially brother relationship in this spread. Hence, the socioeconomic state was associated with the transmission rate of virus in the family.
format Online
Article
Text
id pubmed-5118849
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Shaheed Beheshti University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-51188492016-11-28 Evaluation of hepatitis C virus intrafamilial transmission among families with one index case, a pilot study from Fars province, Iran Lankarani, Kamran B. Ardebili, Maryam Sepehrimanesh, Masood Nejabat, Maryam Hemmati Rad, Mohammad Amir Hosseini, Seyed Younes Gastroenterol Hepatol Bed Bench Original Article AIM: Our aim was to survey the rate and risk factors for Hepatitis C virus interfamilial transmission among families with one index case. BACKGROUND: The role of intrafamilial transmission in Hepatitis C virus epidemiology is still debated. PATIENTS AND METHODS: A cross-sectional study was conducted on 34 families (236 members) of HCV infected patients from Fars province, spring to summer 2013. All subjects were first evaluated for the risk factors of exposure and then their serum was checked for the presence of HCV antibody and the genome, using ELISA and PCR. The genotype of all PCR positive cases was also determined by a commercial assay. Two independent sample t test and Chi-Square test were used to compare groups together. RESULTS: In 18 out of 34 families, HCV antibody was detected (52.9%) in new members. Among them, HCV transmission in 11 families (32%) was also confirmed by PCR. Having a history of intravenous drug abuse (P=0.006) and incarceration (P=0.01) showed to be important risk factors for interfamilial transmission. Hence, blade/needle sharing (P=0.016) just following molecular assay and sex (P=036) only in the serologic analysis were also determined as significant risk factors. Furthermore, based on serologic results, medium socioeconomic state was further associated with this manner of transmission (P=0.019 and P=0.328). Interestingly, among relatives, 13 cases were brothers while just 5 cases were couples. The genotypes 3a and 1a were more prevalent among the population. CONCLUSION: In conclusion, our finding highlighted a noticeable role of interfamilial transmission for HCV spread and supports the significant role of close relatives, especially brother relationship in this spread. Hence, the socioeconomic state was associated with the transmission rate of virus in the family. Shaheed Beheshti University of Medical Sciences 2016 /pmc/articles/PMC5118849/ /pubmed/27895850 Text en ©2016 RIGLD, Research Institute for Gastroenterology and Liver Diseases This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lankarani, Kamran B.
Ardebili, Maryam
Sepehrimanesh, Masood
Nejabat, Maryam
Hemmati Rad, Mohammad Amir
Hosseini, Seyed Younes
Evaluation of hepatitis C virus intrafamilial transmission among families with one index case, a pilot study from Fars province, Iran
title Evaluation of hepatitis C virus intrafamilial transmission among families with one index case, a pilot study from Fars province, Iran
title_full Evaluation of hepatitis C virus intrafamilial transmission among families with one index case, a pilot study from Fars province, Iran
title_fullStr Evaluation of hepatitis C virus intrafamilial transmission among families with one index case, a pilot study from Fars province, Iran
title_full_unstemmed Evaluation of hepatitis C virus intrafamilial transmission among families with one index case, a pilot study from Fars province, Iran
title_short Evaluation of hepatitis C virus intrafamilial transmission among families with one index case, a pilot study from Fars province, Iran
title_sort evaluation of hepatitis c virus intrafamilial transmission among families with one index case, a pilot study from fars province, iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118849/
https://www.ncbi.nlm.nih.gov/pubmed/27895850
work_keys_str_mv AT lankaranikamranb evaluationofhepatitiscvirusintrafamilialtransmissionamongfamilieswithoneindexcaseapilotstudyfromfarsprovinceiran
AT ardebilimaryam evaluationofhepatitiscvirusintrafamilialtransmissionamongfamilieswithoneindexcaseapilotstudyfromfarsprovinceiran
AT sepehrimaneshmasood evaluationofhepatitiscvirusintrafamilialtransmissionamongfamilieswithoneindexcaseapilotstudyfromfarsprovinceiran
AT nejabatmaryam evaluationofhepatitiscvirusintrafamilialtransmissionamongfamilieswithoneindexcaseapilotstudyfromfarsprovinceiran
AT hemmatiradmohammadamir evaluationofhepatitiscvirusintrafamilialtransmissionamongfamilieswithoneindexcaseapilotstudyfromfarsprovinceiran
AT hosseiniseyedyounes evaluationofhepatitiscvirusintrafamilialtransmissionamongfamilieswithoneindexcaseapilotstudyfromfarsprovinceiran