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Widespread recovery of methylation at gametic imprints in hypomethylated mouse stem cells following rescue with DNMT3A2

BACKGROUND: Imprinted loci are paradigms of epigenetic regulation and are associated with a number of genetic disorders in human. A key characteristic of imprints is the presence of a gametic differentially methylated region (gDMR). Previous studies have indicated that DNA methylation lost from gDMR...

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Detalles Bibliográficos
Autores principales:	Thakur, Avinash, Mackin, Sarah-Jayne, Irwin, Rachelle E., O’Neill, Karla M., Pollin, Gareth, Walsh, Colum
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118886/ https://www.ncbi.nlm.nih.gov/pubmed/27895716 http://dx.doi.org/10.1186/s13072-016-0104-2

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