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Metabolic dysfunction in female mice with disruption of 5α-reductase 1

5α-Reductases irreversibly catalyse A-ring reduction of pregnene steroids, including glucocorticoids and androgens. Genetic disruption of 5α-reductase 1 in male mice impairs glucocorticoid clearance and predisposes to glucose intolerance and hepatic steatosis upon metabolic challenge. However, it is...

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Detalles Bibliográficos
Autores principales:	Livingstone, Dawn E W, Di Rollo, Emma M, Mak, Tracy C-S, Sooy, Karen, Walker, Brian R, Andrew, Ruth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118938/ https://www.ncbi.nlm.nih.gov/pubmed/27647861 http://dx.doi.org/10.1530/JOE-16-0125

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