Cargando…

Ligation of CD40 in Human Müller Cells Induces P2X(7) Receptor–Dependent Death of Retinal Endothelial Cells

PURPOSE: Cluster of differentiation 40 (CD40) is required for retinal capillary degeneration in diabetic mice, a process mediated by the retinal endothelial cells (REC) death. However, CD40 activates prosurvival signals in endothelial cells. The purpose of this study was to identify a mechanism by w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Portillo, Jose-Andres C., Lopez Corcino, Yalitza, Dubyak, George R., Kern, Timothy S., Matsuyama, Shigemi, Subauste, Carlos S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2016
Materias:	Retina
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119488/ https://www.ncbi.nlm.nih.gov/pubmed/27893093 http://dx.doi.org/10.1167/iovs.16-20301

Ejemplares similares

CD40 in Retinal Müller Cells Induces P2X(7)-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy
por: Portillo, Jose-Andres C., et al.
Publicado: (2017)

CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells
por: Greene, Jennifer A., et al.
Publicado: (2015)

CD40 Expressed in Endothelial Cells Promotes Upregulation of ICAM-1 But Not Pro-Inflammatory Cytokines, NOS2 and P2X(7) in the Diabetic Retina
por: Yu, Jin-Sang, et al.
Publicado: (2021)

Disruption of retinal inflammation and the development of diabetic retinopathy in mice by a CD40-derived peptide or mutation of CD40 in Müller cells
por: Portillo, Jose-Andres C., et al.
Publicado: (2022)

Epidermal growth factor receptor promotes cerebral and retinal invasion by Toxoplasma gondii
por: Corcino, Yalitza Lopez, et al.
Publicado: (2019)

Photoreceptor Cells Produce Inflammatory Mediators That Contribute to Endothelial Cell Death in Diabetes
por: Tonade, Deoye, et al.
Publicado: (2016)

Presumed Müller Cell Activation in Multiple Evanescent White Dot Syndrome
por: Cicinelli, Maria Vittoria, et al.
Publicado: (2023)

CD40 Upregulation in the Retina of Patients With Diabetic Retinopathy: Association With TRAF2/TRAF6 Upregulation and Inflammatory Molecule Expression
por: Vos, Sarah, et al.
Publicado: (2023)

Neurofibromin Deficiency Induces Endothelial Cell Proliferation and Retinal Neovascularization
por: Zhang, Hanfang, et al.
Publicado: (2018)

Stimulation of Retinal Pigment Epithelium With an α7 nAChR Agonist Leads to Müller Glia Dependent Neurogenesis in the Adult Mammalian Retina
por: Webster, Mark K., et al.
Publicado: (2019)

Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes
por: Liu, Haitao, et al.
Publicado: (2016)

Sox2-Deficient Müller Glia Disrupt the Structural and Functional Maturation of the Mammalian Retina
por: Bachleda, Amelia R., et al.
Publicado: (2016)

MicroRNA-92a-3p Regulates Retinal Angiogenesis by Targeting SGK3 in Vascular Endothelial Cells
por: Cui, Yamei, et al.
Publicado: (2022)

(+)-Pentazocine Reduces NMDA-Induced Murine Retinal Ganglion Cell Death Through a σR1-Dependent Mechanism
por: Zhao, Jing, et al.
Publicado: (2016)

Plasma Kallikrein Mediates Vascular Endothelial Growth Factor–Induced Retinal Dysfunction and Thickening
por: Clermont, Allen, et al.
Publicado: (2016)

Bone Marrow–Derived Cell Recruitment to the Neurosensory Retina and Retinal Pigment Epithelial Cell Layer Following Subthreshold Retinal Phototherapy
por: Caballero, Sergio, et al.
Publicado: (2017)

All-trans-Retinaldehyde Contributes to Retinal Vascular Permeability in Ischemia Reperfusion
por: Dreffs, Alyssa, et al.
Publicado: (2020)

Combined Transplantation With Human Mesenchymal Stem Cells Improves Retinal Rescue Effect of Human Fetal RPE Cells in Retinal Degeneration Mouse Model
por: Pan, Ting, et al.
Publicado: (2020)

Characterization of Oxygen Nanobubbles and In Vitro Evaluation of Retinal Cells in Hypoxia
por: Messerschmidt, Victoria, et al.
Publicado: (2023)

Retinal Hydration Assessment With Optical Coherence Tomography: Unraveling Its Significance in Retinal Fluid Dynamics, Macular Edema and Cell Viability
por: İnam, Onur, et al.
Publicado: (2023)

Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation
por: Shaw, Peter X., et al.
Publicado: (2016)

The Absence of Indoleamine 2,3-Dioxygenase Inhibits Retinal Capillary Degeneration in Diabetic Mice
por: Nahomi, Rooban B., et al.
Publicado: (2018)

Toxoplasma gondii induces FAK-Src-STAT3 signaling during infection of host cells that prevents parasite targeting by autophagy
por: Portillo, Jose-Andres C., et al.
Publicado: (2017)

The Role of Retinal Connexins Cx36 and Horizontal Cell Coupling in Emmetropization in Guinea Pigs
por: Zhi, Zhina, et al.
Publicado: (2021)

A Microfluidic Platform for the Time-Resolved Interrogation of Polarized Retinal Pigment Epithelial Cells
por: Spivey, Eric C., et al.
Publicado: (2023)

Spectrum of Disease Severity in Patients With X-Linked Retinitis Pigmentosa Due to RPGR Mutations
por: Di Iorio, Valentina, et al.
Publicado: (2020)

Changes in Retinal Vessel and Retinal Layer Thickness After Vitrectomy in Retinal Detachment via Swept-Source OCT Angiography
por: Hong, Eun Hee, et al.
Publicado: (2020)

Retinal Vascular Plexuses Are Unequally Affected in Canine Inherited Retinal Degenerations
por: Ripolles-Garcia, Ana, et al.
Publicado: (2022)

The Effects of Diabetic Retinopathy and Pan-Retinal Photocoagulation on Photoreceptor Cell Function as Assessed by Dark Adaptometry
por: Bavinger, J. Clay, et al.
Publicado: (2016)

The Retinal Ganglion Cell Response to Blast-Mediated Traumatic Brain Injury Is Genetic Background Dependent
por: Harper, Matthew M., et al.
Publicado: (2021)

Sigma-1R Protects Retinal Ganglion Cells in Optic Nerve Crush Model for Glaucoma
por: Li, Linya, et al.
Publicado: (2021)

Cone Spacing Correlates With Retinal Thickness and Microperimetry in Patients With Inherited Retinal Degenerations
por: Foote, Katharina G., et al.
Publicado: (2019)

Morphological Analysis of Retinal Microvasculature to Improve Understanding of Retinal Hemorrhage Mechanics in Infants
por: Byrne, Matt P., et al.
Publicado: (2020)

EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development
por: Cao, Xiaowen, et al.
Publicado: (2021)

Hypoxic-Preconditioned Bone Marrow Stem Cell Medium Significantly Improves Outcome After Retinal Ischemia in Rats
por: Roth, Steven, et al.
Publicado: (2016)

Pupillary Light Reflexes in Severe Photoreceptor Blindness Isolate the Melanopic Component of Intrinsically Photosensitive Retinal Ganglion Cells
por: Charng, Jason, et al.
Publicado: (2017)

Vision Recovery and Connectivity by Fetal Retinal Sheet Transplantation in an Immunodeficient Retinal Degenerate Rat Model
por: Seiler, Magdalene J., et al.
Publicado: (2017)

Variability in Capillary Perfusion Is Increased in Regions of Retinal Ischemia Due to Branch Retinal Vein Occlusion
por: Hein, Martin, et al.
Publicado: (2023)

Kamuvudine-9 Protects Retinal Structure and Function in a Novel Model of Experimental Rhegmatogenous Retinal Detachment
por: Huang, Peirong, et al.
Publicado: (2023)

Outer retinal corrugations in late-onset retinal degeneration: a diagnostic finding demonstrated with multimodal imaging
por: Duncan, Holly Joan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_97lgskooarmvamnu1be3vmo4ea