Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease

As stated by the prevailing amyloid cascade hypothesis, Alzheimer's disease (AD) is caused by the aggregation and cerebral deposition of long amyloid‐β peptide (Aβ) species, which are released from a C‐terminal amyloid precursor protein fragment by γ‐secretase. Mutations in its catalytic subuni...

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Detalles Bibliográficos
Autores principales: Kretner, Benedikt, Trambauer, Johannes, Fukumori, Akio, Mielke, Janina, Kuhn, Peer‐Hendrik, Kremmer, Elisabeth, Giese, Armin, Lichtenthaler, Stefan F, Haass, Christian, Arzberger, Thomas, Steiner, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119496/
https://www.ncbi.nlm.nih.gov/pubmed/26988102
http://dx.doi.org/10.15252/emmm.201505952

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