Cargando…

Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases

BACKGROUND: Human papillomaviruses (HPVs) are causally associated with the tumorigenesis of several classes of cancers. However, the prevalence of HPV in gastric cancer (GC) has not yet been systematically reviewed. Hence, a meta-analysis was conducted to estimate the HPV prevalence in patients with...

Descripción completa

Detalles Bibliográficos
Autores principales: Zeng, Zhi-ming, Luo, Fei-fei, Zou, Lin-xia, He, Rong-quan, Pan, Deng-hua, Chen, Xin, Xie, Ting-ting, Li, Yuan-qing, Peng, Zhi-gang, Chen, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119622/
https://www.ncbi.nlm.nih.gov/pubmed/27895502
http://dx.doi.org/10.2147/OTT.S115053
_version_ 1782469103055798272
author Zeng, Zhi-ming
Luo, Fei-fei
Zou, Lin-xia
He, Rong-quan
Pan, Deng-hua
Chen, Xin
Xie, Ting-ting
Li, Yuan-qing
Peng, Zhi-gang
Chen, Gang
author_facet Zeng, Zhi-ming
Luo, Fei-fei
Zou, Lin-xia
He, Rong-quan
Pan, Deng-hua
Chen, Xin
Xie, Ting-ting
Li, Yuan-qing
Peng, Zhi-gang
Chen, Gang
author_sort Zeng, Zhi-ming
collection PubMed
description BACKGROUND: Human papillomaviruses (HPVs) are causally associated with the tumorigenesis of several classes of cancers. However, the prevalence of HPV in gastric cancer (GC) has not yet been systematically reviewed. Hence, a meta-analysis was conducted to estimate the HPV prevalence in patients with GC, and its potential etiologic significance was assessed. METHODS: The pooled HPV prevalence and 95% confidence intervals (CIs) were estimated among all GC patients. Heterogeneity was described by using the I(2) statistic. Sources of heterogeneity were explored by meta-regression and stratified analyses. The meta-influence was applied to evaluate the influence of a single study on the pooled estimates. Odds ratios (ORs) and 95% CIs were computed for case–control studies. For research providing clinicopathological parameters of age, sex, pathological, differentiated, and clinical stages, and HPV subtypes, the corresponding pooled ORs and 95% CIs were also calculated. RESULTS: Thirty studies were included in the current meta-analysis, involving 1,917 patients with GC and 576 controls. The pooled HPV prevalence was 28.0% (95% CI: 23.2%, 32.7%) among all the patients with GC, and the I(2) was 96.9% (P<0.001). A pooled OR of 7.388 (95% CI: 3.876, 14.082) was achieved based on 15 case–control studies (I(2)=56.7%, P=0.004). Moreover, the HPV prevalence was significantly higher in patients from China than in those from non-Chinese regions (31% vs 9%, I(2)=95.0%, P<0.001). The pooled prevalence of HPV16 was 21% in GC tissues, and the pooled prevalence of HPV18 was 7% with an OR of 3.314 (95% CI =1.617, 6.792). HPV16 was 3 times more frequently detected than HPV18. CONCLUSION: HPV could play a potential role in the pathogenesis of GC. A causal relationship can be confirmed only by detecting HPV in the cells of GC precursor lesions (gastric dysplasia or adenoma). In addition, this study might be beneficial for expounding the potential etiologic significance of molecular mechanism of gastric tumorigenesis and providing opinions regarding precautionary measures.
format Online
Article
Text
id pubmed-5119622
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-51196222016-11-28 Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases Zeng, Zhi-ming Luo, Fei-fei Zou, Lin-xia He, Rong-quan Pan, Deng-hua Chen, Xin Xie, Ting-ting Li, Yuan-qing Peng, Zhi-gang Chen, Gang Onco Targets Ther Original Research BACKGROUND: Human papillomaviruses (HPVs) are causally associated with the tumorigenesis of several classes of cancers. However, the prevalence of HPV in gastric cancer (GC) has not yet been systematically reviewed. Hence, a meta-analysis was conducted to estimate the HPV prevalence in patients with GC, and its potential etiologic significance was assessed. METHODS: The pooled HPV prevalence and 95% confidence intervals (CIs) were estimated among all GC patients. Heterogeneity was described by using the I(2) statistic. Sources of heterogeneity were explored by meta-regression and stratified analyses. The meta-influence was applied to evaluate the influence of a single study on the pooled estimates. Odds ratios (ORs) and 95% CIs were computed for case–control studies. For research providing clinicopathological parameters of age, sex, pathological, differentiated, and clinical stages, and HPV subtypes, the corresponding pooled ORs and 95% CIs were also calculated. RESULTS: Thirty studies were included in the current meta-analysis, involving 1,917 patients with GC and 576 controls. The pooled HPV prevalence was 28.0% (95% CI: 23.2%, 32.7%) among all the patients with GC, and the I(2) was 96.9% (P<0.001). A pooled OR of 7.388 (95% CI: 3.876, 14.082) was achieved based on 15 case–control studies (I(2)=56.7%, P=0.004). Moreover, the HPV prevalence was significantly higher in patients from China than in those from non-Chinese regions (31% vs 9%, I(2)=95.0%, P<0.001). The pooled prevalence of HPV16 was 21% in GC tissues, and the pooled prevalence of HPV18 was 7% with an OR of 3.314 (95% CI =1.617, 6.792). HPV16 was 3 times more frequently detected than HPV18. CONCLUSION: HPV could play a potential role in the pathogenesis of GC. A causal relationship can be confirmed only by detecting HPV in the cells of GC precursor lesions (gastric dysplasia or adenoma). In addition, this study might be beneficial for expounding the potential etiologic significance of molecular mechanism of gastric tumorigenesis and providing opinions regarding precautionary measures. Dove Medical Press 2016-11-17 /pmc/articles/PMC5119622/ /pubmed/27895502 http://dx.doi.org/10.2147/OTT.S115053 Text en © 2016 Zeng et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Zeng, Zhi-ming
Luo, Fei-fei
Zou, Lin-xia
He, Rong-quan
Pan, Deng-hua
Chen, Xin
Xie, Ting-ting
Li, Yuan-qing
Peng, Zhi-gang
Chen, Gang
Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases
title Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases
title_full Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases
title_fullStr Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases
title_full_unstemmed Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases
title_short Human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases
title_sort human papillomavirus as a potential risk factor for gastric cancer: a meta-analysis of 1,917 cases
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119622/
https://www.ncbi.nlm.nih.gov/pubmed/27895502
http://dx.doi.org/10.2147/OTT.S115053
work_keys_str_mv AT zengzhiming humanpapillomavirusasapotentialriskfactorforgastriccancerametaanalysisof1917cases
AT luofeifei humanpapillomavirusasapotentialriskfactorforgastriccancerametaanalysisof1917cases
AT zoulinxia humanpapillomavirusasapotentialriskfactorforgastriccancerametaanalysisof1917cases
AT herongquan humanpapillomavirusasapotentialriskfactorforgastriccancerametaanalysisof1917cases
AT pandenghua humanpapillomavirusasapotentialriskfactorforgastriccancerametaanalysisof1917cases
AT chenxin humanpapillomavirusasapotentialriskfactorforgastriccancerametaanalysisof1917cases
AT xietingting humanpapillomavirusasapotentialriskfactorforgastriccancerametaanalysisof1917cases
AT liyuanqing humanpapillomavirusasapotentialriskfactorforgastriccancerametaanalysisof1917cases
AT pengzhigang humanpapillomavirusasapotentialriskfactorforgastriccancerametaanalysisof1917cases
AT chengang humanpapillomavirusasapotentialriskfactorforgastriccancerametaanalysisof1917cases