Cargando…

A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam

The effect of 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (ECyd) on proton-induced cell death was evaluated in human lung carcinoma cell line A549 and Chinese hamster fibroblast cell line V79 to enhance relative biological effectiveness (RBE) within the spread-out Bragg peak (SOBP) of proton bea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maeda, Kenichiro, Yasui, Hironobu, Yamamori, Tohru, Matsuura, Taeko, Takao, Seishin, Suzuki, Motofumi, Matsuda, Akira, Inanami, Osamu, Shirato, Hiroki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119790/ https://www.ncbi.nlm.nih.gov/pubmed/27875573 http://dx.doi.org/10.1371/journal.pone.0166848

Ejemplares similares

A nucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression
por: Meike, Shunsuke, et al.
Publicado: (2011)

Antitumor Activity and Pharmacokinetics of TAS‐106, l‐(3‐C‐Ethynyl‐β‐D‐ribo‐pentofuranosyl)cytosine
por: Shimamoto, Yuji, et al.
Publicado: (2001)

Evaluation of the relative biological effectiveness of spot-scanning proton irradiation in vitro
por: Maeda, Kenichiro, et al.
Publicado: (2016)

Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after x-irradiation
por: Yamamori, Tohru, et al.
Publicado: (2015)

Indirect action to cell killing by SOBP carbon-ion beams
por: Hirayama, Ryoichi, et al.
Publicado: (2014)

Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells
por: Eitaki, Masato, et al.
Publicado: (2012)

3-Methyl pyruvate enhances radiosensitivity through increasing mitochondria-derived reactive oxygen species in tumor cell lines
por: Nishida, Naoya, et al.
Publicado: (2014)

The Association of Standardized Patient Educators (ASPE) Standards of Best Practice (SOBP)
por: Lewis, Karen L., et al.
Publicado: (2017)

Radiation-induced abnormal centrosome amplification and mitotic catastrophe in human cervical tumor HeLa cells and murine mammary tumor EMT6 cells
por: Fujimoto, Masaki, et al.
Publicado: (2020)

MK-8776, a novel Chk1 inhibitor, exhibits an improved radiosensitizing effect compared to UCN-01 by exacerbating radiation-induced aberrant mitosis
por: Suzuki, Motofumi, et al.
Publicado: (2017)

Dynamic gating window technique for the reduction of dosimetric error in respiratory‐gated spot‐scanning particle therapy: An initial phantom study using patient tumor trajectory data
por: Miyamoto, Naoki, et al.
Publicado: (2020)

Synthesis of a 3′-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides
por: Hulpia, Fabian, et al.
Publicado: (2018)

RiboFlow, RiboR and RiboPy: an ecosystem for analyzing ribosome profiling data at read length resolution
por: Ozadam, Hakan, et al.
Publicado: (2020)

Cellular and Biochemical Mechanisms of the Resistance of Human Cancer Cells to a New Anticancer Ribo‐nucleoside, TAS‐106
por: Shimamoto, Yuji, et al.
Publicado: (2002)

Prediction of target position from multiple fiducial markers by partial least squares regression in real-time tumor-tracking radiation therapy
por: Ukon, Kanako, et al.
Publicado: (2021)

Are Bragg Peaks Gaussian?
por: Hammouda, Boualem
Publicado: (2014)

Analysis of the mechanism of radiation-induced upregulation of mitochondrial abundance in mouse fibroblasts
por: Yamamori, Tohru, et al.
Publicado: (2017)

RiboProfiling: a Bioconductor package for standard Ribo-seq pipeline processing
por: Popa, Alexandra, et al.
Publicado: (2016)

RiboPlotR: a visualization tool for periodic Ribo-seq reads
por: Wu, Hsin-Yen Larry, et al.
Publicado: (2021)

A simulation study on the dosimetric benefit of real-time motion compensation in spot-scanning proton therapy for prostate
por: Fujii, Yusuke, et al.
Publicado: (2017)

Monte Carlo-Based Radiobiological Investigation of the Most Optimal Ion Beam Forming SOBP for Particle Therapy
por: Kantemiris, Ioannis, et al.
Publicado: (2022)

CircSOBP suppresses the progression of glioma by disrupting glycolysis and promoting the MDA5-mediated immune response
por: Mu, Maolin, et al.
Publicado: (2023)

Sensitivity of Human Cancer Cells to the New Anticancer Ribo‐nucleoside TAS–106 Is Correlated with Expression of Uridine‐cytidine Kinase 2
por: Shimamoto, Yuji, et al.
Publicado: (2002)

Nucleolipids of Canonical Purine ß‐d‐Ribo‐Nucleosides: Synthesis and Cytostatic/Cytotoxic Activities Toward Human and Rat Glioblastoma Cells
por: Knies, Christine, et al.
Publicado: (2015)

Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase
por: Tomar, Rachana, et al.
Publicado: (2023)

The prospective application of a hypoxic radiosensitizer, doranidazole to rat intracranial glioblastoma with blood brain barrier disruption
por: Yasui, Hironobu, et al.
Publicado: (2013)

RiboDiPA: a novel tool for differential pattern analysis in Ribo-seq data
por: Li, Keren, et al.
Publicado: (2020)

Ribo-ODDR: oligo design pipeline for experiment-specific rRNA depletion in Ribo-seq
por: Alkan, Ferhat, et al.
Publicado: (2021)

Evaluation of proton beam radiation-induced skin injury in a murine model using a clinical SOBP
por: Pisciotta, Pietro, et al.
Publicado: (2020)

A motion-compensated image filter for low-dose fluoroscopy in a real-time tumor-tracking radiotherapy system
por: Miyamoto, Naoki, et al.
Publicado: (2015)

Deletion Mutants of Human Deoxycytidine Kinase mRNA in Cells Resistant to Antitumor Cytosine Nucleosides
por: Obata, Tohru, et al.
Publicado: (2001)

Antitumor Effect of Sugar-Modified Cytosine Nucleosides on Growth of Adult T-Cell Leukemia Cells in Mice
por: Maeda, Naoyoshi, et al.
Publicado: (2020)

Practical Synthesis of Ethynyl(phenyl)-λ(3)-Iodane Using Calcium Carbide as an Ethynyl Group Source
por: Hashishin, Takahiro, et al.
Publicado: (2020)

RiboStreamR: a web application for quality control, analysis, and visualization of Ribo-seq data
por: Perkins, Patrick, et al.
Publicado: (2019)

9-Ethynyl-9H-carbazole
por: Tabata, Hideyuki, et al.
Publicado: (2012)

Visualization of the Nucleolus Using Ethynyl Uridine
por: Dvořáčková, Martina, et al.
Publicado: (2018)

BraggNN: fast X-ray Bragg peak analysis using deep learning
por: Liu, Zhengchun, et al.
Publicado: (2021)

The potential of the riboSNitch in personalized medicine
por: Solem, Amanda C., et al.
Publicado: (2015)

Dr Jekyll and Mr Hyde: a strange case of 5-ethynyl-2′-deoxyuridine and 5-ethynyl-2′-deoxycytidine
por: Ligasová, Anna, et al.
Publicado: (2016)

4-(Dimethylamino)phenyl ethynyl telluride
por: Farran, Joan, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_0eklq4mslp7v36ngkjpgelrclr