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Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment
OBJECTIVE: As there are pharmacological differences between males and females, and glucocorticoid (GC) treatment is associated with increased cardiovascular mortality rate in rheumatoid arthritis (RA) patients, it is important to study serum polar lipid profiles of male and female patients in respon...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119840/ https://www.ncbi.nlm.nih.gov/pubmed/27682325 http://dx.doi.org/10.1007/s10787-016-0284-1 |
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author | Fu, Junzeng Cuppen, Bart V. J. Welsing, Paco M. J. van Wietmarschen, Herman Harms, Amy C. Berger, Ruud Koval, Slavik Fritsch-Stork, Ruth D. E. Bijlsma, Johannes W. J. Hankemeier, Thomas van der Greef, Jan Lafeber, Floris P. J. G. |
author_facet | Fu, Junzeng Cuppen, Bart V. J. Welsing, Paco M. J. van Wietmarschen, Herman Harms, Amy C. Berger, Ruud Koval, Slavik Fritsch-Stork, Ruth D. E. Bijlsma, Johannes W. J. Hankemeier, Thomas van der Greef, Jan Lafeber, Floris P. J. G. |
author_sort | Fu, Junzeng |
collection | PubMed |
description | OBJECTIVE: As there are pharmacological differences between males and females, and glucocorticoid (GC) treatment is associated with increased cardiovascular mortality rate in rheumatoid arthritis (RA) patients, it is important to study serum polar lipid profiles of male and female patients in response to GC therapy. Gender differences may require an adjustment to the treatment strategy for a selection of patients. METHODS: Serum samples from 281 RA patients were analysed using a targeted lipidomics platform. The differences in GC use and gender on polar lipid profiles were cross sectionally examined by multiple linear regressions, while correcting for confounding factors. RESULTS: Differences in polar lipids between GC users and non-GC users in females and males were merely restricted to lysophospholipids (lysophosphatidylcholines and lysophosphatidylethanolamines). Lysophospholipids in female patients treated with GCs were significantly higher than female patients not treated with GCs (p = 6.0 E−6), whereas no significant difference was observed in male GC users versus non-users (p = 0.397). CONCLUSION: The lysophospholipid profiles in response to GCs were significantly different between male and female RA patients, which may have implications for the cardiovascular risk of GC treatment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10787-016-0284-1) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5119840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-51198402016-12-06 Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment Fu, Junzeng Cuppen, Bart V. J. Welsing, Paco M. J. van Wietmarschen, Herman Harms, Amy C. Berger, Ruud Koval, Slavik Fritsch-Stork, Ruth D. E. Bijlsma, Johannes W. J. Hankemeier, Thomas van der Greef, Jan Lafeber, Floris P. J. G. Inflammopharmacology Short Communication OBJECTIVE: As there are pharmacological differences between males and females, and glucocorticoid (GC) treatment is associated with increased cardiovascular mortality rate in rheumatoid arthritis (RA) patients, it is important to study serum polar lipid profiles of male and female patients in response to GC therapy. Gender differences may require an adjustment to the treatment strategy for a selection of patients. METHODS: Serum samples from 281 RA patients were analysed using a targeted lipidomics platform. The differences in GC use and gender on polar lipid profiles were cross sectionally examined by multiple linear regressions, while correcting for confounding factors. RESULTS: Differences in polar lipids between GC users and non-GC users in females and males were merely restricted to lysophospholipids (lysophosphatidylcholines and lysophosphatidylethanolamines). Lysophospholipids in female patients treated with GCs were significantly higher than female patients not treated with GCs (p = 6.0 E−6), whereas no significant difference was observed in male GC users versus non-users (p = 0.397). CONCLUSION: The lysophospholipid profiles in response to GCs were significantly different between male and female RA patients, which may have implications for the cardiovascular risk of GC treatment. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10787-016-0284-1) contains supplementary material, which is available to authorized users. Springer International Publishing 2016-09-28 2016 /pmc/articles/PMC5119840/ /pubmed/27682325 http://dx.doi.org/10.1007/s10787-016-0284-1 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Short Communication Fu, Junzeng Cuppen, Bart V. J. Welsing, Paco M. J. van Wietmarschen, Herman Harms, Amy C. Berger, Ruud Koval, Slavik Fritsch-Stork, Ruth D. E. Bijlsma, Johannes W. J. Hankemeier, Thomas van der Greef, Jan Lafeber, Floris P. J. G. Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment |
title | Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment |
title_full | Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment |
title_fullStr | Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment |
title_full_unstemmed | Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment |
title_short | Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment |
title_sort | differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119840/ https://www.ncbi.nlm.nih.gov/pubmed/27682325 http://dx.doi.org/10.1007/s10787-016-0284-1 |
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