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SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise

Exercise has numerous beneficial metabolic effects. The central nervous system (CNS) is critical for regulating energy balance and coordinating whole body metabolism. However, a role for the CNS in the regulation of metabolism in the context of the exercise remains less clear. Here, using geneticall...

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Autores principales: Fujikawa, Teppei, Castorena, Carlos M, Pearson, Mackenzie, Kusminski, Christine M, Ahmed, Newaz, Battiprolu, Pavan K, Kim, Ki Woo, Lee, Syann, Hill, Joseph A, Scherer, Philipp E, Holland, William L, Elmquist, Joel K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119890/
https://www.ncbi.nlm.nih.gov/pubmed/27874828
http://dx.doi.org/10.7554/eLife.18206
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author Fujikawa, Teppei
Castorena, Carlos M
Pearson, Mackenzie
Kusminski, Christine M
Ahmed, Newaz
Battiprolu, Pavan K
Kim, Ki Woo
Lee, Syann
Hill, Joseph A
Scherer, Philipp E
Holland, William L
Elmquist, Joel K
author_facet Fujikawa, Teppei
Castorena, Carlos M
Pearson, Mackenzie
Kusminski, Christine M
Ahmed, Newaz
Battiprolu, Pavan K
Kim, Ki Woo
Lee, Syann
Hill, Joseph A
Scherer, Philipp E
Holland, William L
Elmquist, Joel K
author_sort Fujikawa, Teppei
collection PubMed
description Exercise has numerous beneficial metabolic effects. The central nervous system (CNS) is critical for regulating energy balance and coordinating whole body metabolism. However, a role for the CNS in the regulation of metabolism in the context of the exercise remains less clear. Here, using genetically engineered mice we assessed the requirement of steroidogenic factor-1 (SF-1) expression in neurons of the ventromedial hypothalamic nucleus (VMH) in mediating the beneficial effects of exercise on metabolism. We found that VMH-specific deletion of SF-1 blunts (a) the reductions in fat mass, (b) improvements in glycemia, and (c) increases in energy expenditure that are associated with exercise training. Unexpectedly, we found that SF-1 deletion in the VMH attenuates metabolic responses of skeletal muscle to exercise, including induction of PGC-1α expression. Collectively, this evidence suggests that SF-1 expression in VMH neurons is required for the beneficial effects of exercise on metabolism. DOI: http://dx.doi.org/10.7554/eLife.18206.001
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spelling pubmed-51198902016-11-28 SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise Fujikawa, Teppei Castorena, Carlos M Pearson, Mackenzie Kusminski, Christine M Ahmed, Newaz Battiprolu, Pavan K Kim, Ki Woo Lee, Syann Hill, Joseph A Scherer, Philipp E Holland, William L Elmquist, Joel K eLife Neuroscience Exercise has numerous beneficial metabolic effects. The central nervous system (CNS) is critical for regulating energy balance and coordinating whole body metabolism. However, a role for the CNS in the regulation of metabolism in the context of the exercise remains less clear. Here, using genetically engineered mice we assessed the requirement of steroidogenic factor-1 (SF-1) expression in neurons of the ventromedial hypothalamic nucleus (VMH) in mediating the beneficial effects of exercise on metabolism. We found that VMH-specific deletion of SF-1 blunts (a) the reductions in fat mass, (b) improvements in glycemia, and (c) increases in energy expenditure that are associated with exercise training. Unexpectedly, we found that SF-1 deletion in the VMH attenuates metabolic responses of skeletal muscle to exercise, including induction of PGC-1α expression. Collectively, this evidence suggests that SF-1 expression in VMH neurons is required for the beneficial effects of exercise on metabolism. DOI: http://dx.doi.org/10.7554/eLife.18206.001 eLife Sciences Publications, Ltd 2016-11-22 /pmc/articles/PMC5119890/ /pubmed/27874828 http://dx.doi.org/10.7554/eLife.18206 Text en © 2016, Fujikawa et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Fujikawa, Teppei
Castorena, Carlos M
Pearson, Mackenzie
Kusminski, Christine M
Ahmed, Newaz
Battiprolu, Pavan K
Kim, Ki Woo
Lee, Syann
Hill, Joseph A
Scherer, Philipp E
Holland, William L
Elmquist, Joel K
SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise
title SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise
title_full SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise
title_fullStr SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise
title_full_unstemmed SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise
title_short SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise
title_sort sf-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119890/
https://www.ncbi.nlm.nih.gov/pubmed/27874828
http://dx.doi.org/10.7554/eLife.18206
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