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Axon degeneration: Linking axonal bioenergetics to myelin
The mechanisms by which axonal degeneration occurs, even in the presence of apparently normal myelin sheaths, remain unknown. In this issue, Yin et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607099) study mutant mice in which proteolipid protein is replaced by the peripheral myelin prot...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119944/ https://www.ncbi.nlm.nih.gov/pubmed/27872250 http://dx.doi.org/10.1083/jcb.201611010 |
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author | Beirowski, Bogdan Babetto, Elisabetta Wrabetz, Lawrence |
author_facet | Beirowski, Bogdan Babetto, Elisabetta Wrabetz, Lawrence |
author_sort | Beirowski, Bogdan |
collection | PubMed |
description | The mechanisms by which axonal degeneration occurs, even in the presence of apparently normal myelin sheaths, remain unknown. In this issue, Yin et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607099) study mutant mice in which proteolipid protein is replaced by the peripheral myelin protein P(0) and describe a number of early axonal abnormalities, which together suggest that aberrant mitochondrial energy metabolism precedes axonal degeneration. |
format | Online Article Text |
id | pubmed-5119944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-51199442017-05-21 Axon degeneration: Linking axonal bioenergetics to myelin Beirowski, Bogdan Babetto, Elisabetta Wrabetz, Lawrence J Cell Biol Commentary The mechanisms by which axonal degeneration occurs, even in the presence of apparently normal myelin sheaths, remain unknown. In this issue, Yin et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607099) study mutant mice in which proteolipid protein is replaced by the peripheral myelin protein P(0) and describe a number of early axonal abnormalities, which together suggest that aberrant mitochondrial energy metabolism precedes axonal degeneration. The Rockefeller University Press 2016-11-21 /pmc/articles/PMC5119944/ /pubmed/27872250 http://dx.doi.org/10.1083/jcb.201611010 Text en © 2016 Beirowski et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Commentary Beirowski, Bogdan Babetto, Elisabetta Wrabetz, Lawrence Axon degeneration: Linking axonal bioenergetics to myelin |
title | Axon degeneration: Linking axonal bioenergetics to myelin |
title_full | Axon degeneration: Linking axonal bioenergetics to myelin |
title_fullStr | Axon degeneration: Linking axonal bioenergetics to myelin |
title_full_unstemmed | Axon degeneration: Linking axonal bioenergetics to myelin |
title_short | Axon degeneration: Linking axonal bioenergetics to myelin |
title_sort | axon degeneration: linking axonal bioenergetics to myelin |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119944/ https://www.ncbi.nlm.nih.gov/pubmed/27872250 http://dx.doi.org/10.1083/jcb.201611010 |
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