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Axon degeneration: Linking axonal bioenergetics to myelin

The mechanisms by which axonal degeneration occurs, even in the presence of apparently normal myelin sheaths, remain unknown. In this issue, Yin et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607099) study mutant mice in which proteolipid protein is replaced by the peripheral myelin prot...

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Detalles Bibliográficos
Autores principales: Beirowski, Bogdan, Babetto, Elisabetta, Wrabetz, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119944/
https://www.ncbi.nlm.nih.gov/pubmed/27872250
http://dx.doi.org/10.1083/jcb.201611010
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author Beirowski, Bogdan
Babetto, Elisabetta
Wrabetz, Lawrence
author_facet Beirowski, Bogdan
Babetto, Elisabetta
Wrabetz, Lawrence
author_sort Beirowski, Bogdan
collection PubMed
description The mechanisms by which axonal degeneration occurs, even in the presence of apparently normal myelin sheaths, remain unknown. In this issue, Yin et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607099) study mutant mice in which proteolipid protein is replaced by the peripheral myelin protein P(0) and describe a number of early axonal abnormalities, which together suggest that aberrant mitochondrial energy metabolism precedes axonal degeneration.
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spelling pubmed-51199442017-05-21 Axon degeneration: Linking axonal bioenergetics to myelin Beirowski, Bogdan Babetto, Elisabetta Wrabetz, Lawrence J Cell Biol Commentary The mechanisms by which axonal degeneration occurs, even in the presence of apparently normal myelin sheaths, remain unknown. In this issue, Yin et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607099) study mutant mice in which proteolipid protein is replaced by the peripheral myelin protein P(0) and describe a number of early axonal abnormalities, which together suggest that aberrant mitochondrial energy metabolism precedes axonal degeneration. The Rockefeller University Press 2016-11-21 /pmc/articles/PMC5119944/ /pubmed/27872250 http://dx.doi.org/10.1083/jcb.201611010 Text en © 2016 Beirowski et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Beirowski, Bogdan
Babetto, Elisabetta
Wrabetz, Lawrence
Axon degeneration: Linking axonal bioenergetics to myelin
title Axon degeneration: Linking axonal bioenergetics to myelin
title_full Axon degeneration: Linking axonal bioenergetics to myelin
title_fullStr Axon degeneration: Linking axonal bioenergetics to myelin
title_full_unstemmed Axon degeneration: Linking axonal bioenergetics to myelin
title_short Axon degeneration: Linking axonal bioenergetics to myelin
title_sort axon degeneration: linking axonal bioenergetics to myelin
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119944/
https://www.ncbi.nlm.nih.gov/pubmed/27872250
http://dx.doi.org/10.1083/jcb.201611010
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