Regulation of EGFR surface levels by COPII-dependent trafficking

Cell surface levels of epidermal growth factor receptors (EGFRs) are thought to be controlled mainly by endocytic trafficking, with biosynthetic EGFR trafficking presumed to be a constitutive and unregulated process. However, Scharaw et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.20160109...

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Detalles Bibliográficos
Autor principal: Farhan, Hesso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119945/
https://www.ncbi.nlm.nih.gov/pubmed/27872251
http://dx.doi.org/10.1083/jcb.201611014
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author Farhan, Hesso
author_facet Farhan, Hesso
author_sort Farhan, Hesso
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description Cell surface levels of epidermal growth factor receptors (EGFRs) are thought to be controlled mainly by endocytic trafficking, with biosynthetic EGFR trafficking presumed to be a constitutive and unregulated process. However, Scharaw et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601090) demonstrate a role for inducible COPII trafficking in controlling EGFR surface levels.
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spelling pubmed-51199452017-05-21 Regulation of EGFR surface levels by COPII-dependent trafficking Farhan, Hesso J Cell Biol Commentary Cell surface levels of epidermal growth factor receptors (EGFRs) are thought to be controlled mainly by endocytic trafficking, with biosynthetic EGFR trafficking presumed to be a constitutive and unregulated process. However, Scharaw et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601090) demonstrate a role for inducible COPII trafficking in controlling EGFR surface levels. The Rockefeller University Press 2016-11-21 /pmc/articles/PMC5119945/ /pubmed/27872251 http://dx.doi.org/10.1083/jcb.201611014 Text en © 2016 Farhan This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Farhan, Hesso
Regulation of EGFR surface levels by COPII-dependent trafficking
title Regulation of EGFR surface levels by COPII-dependent trafficking
title_full Regulation of EGFR surface levels by COPII-dependent trafficking
title_fullStr Regulation of EGFR surface levels by COPII-dependent trafficking
title_full_unstemmed Regulation of EGFR surface levels by COPII-dependent trafficking
title_short Regulation of EGFR surface levels by COPII-dependent trafficking
title_sort regulation of egfr surface levels by copii-dependent trafficking
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119945/
https://www.ncbi.nlm.nih.gov/pubmed/27872251
http://dx.doi.org/10.1083/jcb.201611014
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