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Study of dienogest for dysmenorrhea and pelvic pain associated with endometriosis

OBJECTIVE: To evaluate the effect of orally administered dienogest (DNG) for dysmenorrhea and pelvic pain associated with endometriosis. METHODS: For this study we recruited 89 patients with dysmenorrhea and pelvic pain associated with endometriosis diagnosed by laparoscopy. All patients complained...

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Autores principales: Kim, Soo Ah, Um, Mi Jung, Kim, Han Kyoung, Kim, Suk Jin, Moon, Seo Ju, Jung, Hyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120070/
https://www.ncbi.nlm.nih.gov/pubmed/27896253
http://dx.doi.org/10.5468/ogs.2016.59.6.506
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author Kim, Soo Ah
Um, Mi Jung
Kim, Han Kyoung
Kim, Suk Jin
Moon, Seo Ju
Jung, Hyuk
author_facet Kim, Soo Ah
Um, Mi Jung
Kim, Han Kyoung
Kim, Suk Jin
Moon, Seo Ju
Jung, Hyuk
author_sort Kim, Soo Ah
collection PubMed
description OBJECTIVE: To evaluate the effect of orally administered dienogest (DNG) for dysmenorrhea and pelvic pain associated with endometriosis. METHODS: For this study we recruited 89 patients with dysmenorrhea and pelvic pain associated with endometriosis diagnosed by laparoscopy. All patients complained of persistent dysmenorrhea and pelvic pain despite surgical treatment 6 months previously. After 6 months of DNG treatment, we used a 0 to 3 point verbal rating scale to measure the severity of disability in daily life due to dysmenorrhea and pelvic pain, and the use of analgesics. Weight gain, serum lipid and liver enzyme tests were performed before treatment and after 6 months of DNG treatment. RESULTS: Total dysmenorrhea scores assessed by the verbal rating scale significantly decreased by the end of treatment (P<0.001). The mean (±standard deviation) pain score for dysmenorrhea before and after treatment were 1.42±1.1 and 0.1±0.3, respectively. The mean non-menstrual pelvic pain scores before and after treatment were 0.52±0.6 and 0.18±0.3, respectively, showing a significant difference (P<0.001). The use of analgesics significantly decreased by the end of the treatment (P<0.001). The associated adverse effects were weight gains (in 56 of 89 patients, 63%) and uterine bleeding (in 28 of 89 patients, 31.5%). The weight gain (before treatment, 57.9±9.7; after treatment, 61.1±12.6) was statistically significant (P<0.040). CONCLUSION: This study demonstrated that orally administered DNG could be used to effectively treat dysmenorrhea and pelvic pain associated with endometriosis although the side effects of weight gain and uterine bleeding should be considered.
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spelling pubmed-51200702016-11-28 Study of dienogest for dysmenorrhea and pelvic pain associated with endometriosis Kim, Soo Ah Um, Mi Jung Kim, Han Kyoung Kim, Suk Jin Moon, Seo Ju Jung, Hyuk Obstet Gynecol Sci Original Article OBJECTIVE: To evaluate the effect of orally administered dienogest (DNG) for dysmenorrhea and pelvic pain associated with endometriosis. METHODS: For this study we recruited 89 patients with dysmenorrhea and pelvic pain associated with endometriosis diagnosed by laparoscopy. All patients complained of persistent dysmenorrhea and pelvic pain despite surgical treatment 6 months previously. After 6 months of DNG treatment, we used a 0 to 3 point verbal rating scale to measure the severity of disability in daily life due to dysmenorrhea and pelvic pain, and the use of analgesics. Weight gain, serum lipid and liver enzyme tests were performed before treatment and after 6 months of DNG treatment. RESULTS: Total dysmenorrhea scores assessed by the verbal rating scale significantly decreased by the end of treatment (P<0.001). The mean (±standard deviation) pain score for dysmenorrhea before and after treatment were 1.42±1.1 and 0.1±0.3, respectively. The mean non-menstrual pelvic pain scores before and after treatment were 0.52±0.6 and 0.18±0.3, respectively, showing a significant difference (P<0.001). The use of analgesics significantly decreased by the end of the treatment (P<0.001). The associated adverse effects were weight gains (in 56 of 89 patients, 63%) and uterine bleeding (in 28 of 89 patients, 31.5%). The weight gain (before treatment, 57.9±9.7; after treatment, 61.1±12.6) was statistically significant (P<0.040). CONCLUSION: This study demonstrated that orally administered DNG could be used to effectively treat dysmenorrhea and pelvic pain associated with endometriosis although the side effects of weight gain and uterine bleeding should be considered. Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2016-11 2016-11-15 /pmc/articles/PMC5120070/ /pubmed/27896253 http://dx.doi.org/10.5468/ogs.2016.59.6.506 Text en Copyright © 2016 Korean Society of Obstetrics and Gynecology http://creativecommons.org/licenses/by-nc/3.0/ Articles published in Obstet Gynecol Sci are open-access, distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Soo Ah
Um, Mi Jung
Kim, Han Kyoung
Kim, Suk Jin
Moon, Seo Ju
Jung, Hyuk
Study of dienogest for dysmenorrhea and pelvic pain associated with endometriosis
title Study of dienogest for dysmenorrhea and pelvic pain associated with endometriosis
title_full Study of dienogest for dysmenorrhea and pelvic pain associated with endometriosis
title_fullStr Study of dienogest for dysmenorrhea and pelvic pain associated with endometriosis
title_full_unstemmed Study of dienogest for dysmenorrhea and pelvic pain associated with endometriosis
title_short Study of dienogest for dysmenorrhea and pelvic pain associated with endometriosis
title_sort study of dienogest for dysmenorrhea and pelvic pain associated with endometriosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120070/
https://www.ncbi.nlm.nih.gov/pubmed/27896253
http://dx.doi.org/10.5468/ogs.2016.59.6.506
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