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Melatonin and Nitrones As Potential Therapeutic Agents for Stroke

Stroke is a disease of aging affecting millions of people worldwide, and recombinant tissue-type plasminogen activator (r-tPA) is the only treatment approved. However, r-tPA has a low therapeutic window and secondary effects which limit its beneficial outcome, urging thus the search for new more eff...

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Autores principales: Romero, Alejandro, Ramos, Eva, Patiño, Paloma, Oset-Gasque, Maria J., López-Muñoz, Francisco, Marco-Contelles, José, Ayuso, María I., Alcázar, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120103/
https://www.ncbi.nlm.nih.gov/pubmed/27932976
http://dx.doi.org/10.3389/fnagi.2016.00281
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author Romero, Alejandro
Ramos, Eva
Patiño, Paloma
Oset-Gasque, Maria J.
López-Muñoz, Francisco
Marco-Contelles, José
Ayuso, María I.
Alcázar, Alberto
author_facet Romero, Alejandro
Ramos, Eva
Patiño, Paloma
Oset-Gasque, Maria J.
López-Muñoz, Francisco
Marco-Contelles, José
Ayuso, María I.
Alcázar, Alberto
author_sort Romero, Alejandro
collection PubMed
description Stroke is a disease of aging affecting millions of people worldwide, and recombinant tissue-type plasminogen activator (r-tPA) is the only treatment approved. However, r-tPA has a low therapeutic window and secondary effects which limit its beneficial outcome, urging thus the search for new more efficient therapies. Among them, neuroprotection based on melatonin or nitrones, as free radical traps, have arisen as drug candidates due to their strong antioxidant power. In this Perspective article, an update on the specific results of the melatonin and several new nitrones are presented.
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spelling pubmed-51201032016-12-08 Melatonin and Nitrones As Potential Therapeutic Agents for Stroke Romero, Alejandro Ramos, Eva Patiño, Paloma Oset-Gasque, Maria J. López-Muñoz, Francisco Marco-Contelles, José Ayuso, María I. Alcázar, Alberto Front Aging Neurosci Neuroscience Stroke is a disease of aging affecting millions of people worldwide, and recombinant tissue-type plasminogen activator (r-tPA) is the only treatment approved. However, r-tPA has a low therapeutic window and secondary effects which limit its beneficial outcome, urging thus the search for new more efficient therapies. Among them, neuroprotection based on melatonin or nitrones, as free radical traps, have arisen as drug candidates due to their strong antioxidant power. In this Perspective article, an update on the specific results of the melatonin and several new nitrones are presented. Frontiers Media S.A. 2016-11-23 /pmc/articles/PMC5120103/ /pubmed/27932976 http://dx.doi.org/10.3389/fnagi.2016.00281 Text en Copyright © 2016 Romero, Ramos, Patiño, Oset-Gasque, López-Muñoz, Marco-Contelles, Ayuso and Alcázar. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Romero, Alejandro
Ramos, Eva
Patiño, Paloma
Oset-Gasque, Maria J.
López-Muñoz, Francisco
Marco-Contelles, José
Ayuso, María I.
Alcázar, Alberto
Melatonin and Nitrones As Potential Therapeutic Agents for Stroke
title Melatonin and Nitrones As Potential Therapeutic Agents for Stroke
title_full Melatonin and Nitrones As Potential Therapeutic Agents for Stroke
title_fullStr Melatonin and Nitrones As Potential Therapeutic Agents for Stroke
title_full_unstemmed Melatonin and Nitrones As Potential Therapeutic Agents for Stroke
title_short Melatonin and Nitrones As Potential Therapeutic Agents for Stroke
title_sort melatonin and nitrones as potential therapeutic agents for stroke
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120103/
https://www.ncbi.nlm.nih.gov/pubmed/27932976
http://dx.doi.org/10.3389/fnagi.2016.00281
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