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The Generalized Relative Pairs IBD Distribution: Its Use in the Detection of Linkage

I introduce a novel approach to derive the distribution of disease affectional status given alleles identical by descent (IBD) sharing through ITO method. My approach tremendously simplifies the calculation of the affectional status distribution compared to the conventional method, which requires th...

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Detalles Bibliográficos
Autor principal: Zou, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120125/
https://www.ncbi.nlm.nih.gov/pubmed/27933287
http://dx.doi.org/10.3389/fpubh.2016.00259
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author Zou, Quan
author_facet Zou, Quan
author_sort Zou, Quan
collection PubMed
description I introduce a novel approach to derive the distribution of disease affectional status given alleles identical by descent (IBD) sharing through ITO method. My approach tremendously simplifies the calculation of the affectional status distribution compared to the conventional method, which requires the parental mating information, and could be applied to disease with both dichotomous trait and quantitative trait locus (QTL). This distribution is shown to be independent of relative relationship and be employed to develop the marker IBD distributions for relative relationship. In addition, three linkage tests: the proportion, the mean test, and the LOD score test are proposed for different relative pairs based on their marker IBD distributions. Among all three tests, the mean test for sib pair requires the least sample size, thus, has the highest power. Finally, I evaluate the significance of different relative relationships by a Monte-Carlo simulation approach.
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spelling pubmed-51201252016-12-08 The Generalized Relative Pairs IBD Distribution: Its Use in the Detection of Linkage Zou, Quan Front Public Health Public Health I introduce a novel approach to derive the distribution of disease affectional status given alleles identical by descent (IBD) sharing through ITO method. My approach tremendously simplifies the calculation of the affectional status distribution compared to the conventional method, which requires the parental mating information, and could be applied to disease with both dichotomous trait and quantitative trait locus (QTL). This distribution is shown to be independent of relative relationship and be employed to develop the marker IBD distributions for relative relationship. In addition, three linkage tests: the proportion, the mean test, and the LOD score test are proposed for different relative pairs based on their marker IBD distributions. Among all three tests, the mean test for sib pair requires the least sample size, thus, has the highest power. Finally, I evaluate the significance of different relative relationships by a Monte-Carlo simulation approach. Frontiers Media S.A. 2016-11-23 /pmc/articles/PMC5120125/ /pubmed/27933287 http://dx.doi.org/10.3389/fpubh.2016.00259 Text en Copyright © 2016 Zou. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Zou, Quan
The Generalized Relative Pairs IBD Distribution: Its Use in the Detection of Linkage
title The Generalized Relative Pairs IBD Distribution: Its Use in the Detection of Linkage
title_full The Generalized Relative Pairs IBD Distribution: Its Use in the Detection of Linkage
title_fullStr The Generalized Relative Pairs IBD Distribution: Its Use in the Detection of Linkage
title_full_unstemmed The Generalized Relative Pairs IBD Distribution: Its Use in the Detection of Linkage
title_short The Generalized Relative Pairs IBD Distribution: Its Use in the Detection of Linkage
title_sort generalized relative pairs ibd distribution: its use in the detection of linkage
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120125/
https://www.ncbi.nlm.nih.gov/pubmed/27933287
http://dx.doi.org/10.3389/fpubh.2016.00259
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