Cargando…

DDIT4 regulates mesenchymal stem cell fate by mediating between HIF1α and mTOR signalling

Stem cell fate decisions to remain quiescent, self-renew or differentiate are largely governed by the interplay between extracellular signals from the niche and the cell intrinsic signal cascades and transcriptional programs. Here we demonstrate that DNA Damage Inducible Transcript 4 (DDIT4) acts as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gharibi, Borzo, Ghuman, Mandeep, Hughes, Francis J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120275/ https://www.ncbi.nlm.nih.gov/pubmed/27876894 http://dx.doi.org/10.1038/srep36889

Ejemplares similares

Akt- and Erk-mediated regulation of proliferation and differentiation during PDGFRβ-induced MSC self-renewal
por: Gharibi, Borzo, et al.
Publicado: (2012)

The physiological mTOR complex 1 inhibitor DDIT4 mediates therapy resistance in glioblastoma
por: Foltyn, Martha, et al.
Publicado: (2019)

PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4
por: Salsman, Jayme, et al.
Publicado: (2017)

Circulating levels of DDIT4 and mTOR, and contributions of BMI, inflammation and insulin sensitivity in hyperlipidemia
por: Pan, Xinyan, et al.
Publicado: (2022)

p53-mediated AKT and mTOR inhibition requires RFX7 and DDIT4 and depends on nutrient abundance
por: Coronel, Luis, et al.
Publicado: (2021)

The m(6)A demethylase ALKBH5-mediated upregulation of DDIT4-AS1 maintains pancreatic cancer stemness and suppresses chemosensitivity by activating the mTOR pathway
por: Zhang, Yi, et al.
Publicado: (2022)

Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling
por: Frith, Jessica E., et al.
Publicado: (2018)

Role of Autophagy Mediated by AMPK/DDiT4/mTOR Axis in HT22 Cells Under Oxygen and Glucose Deprivation/Reoxygenation
por: Zhang, Yi, et al.
Publicado: (2023)

USP10 Contributes to Colon Carcinogenesis via mTOR/S6K Mediated HIF-1α but Not HIF-2α Protein Synthesis
por: Kubaichuk, Kateryna, et al.
Publicado: (2023)

Inflammatory interferon activates HIF-1α-mediated epithelial-to-mesenchymal transition via PI3K/AKT/mTOR pathway
por: Yeh, Yen-Hsiu, et al.
Publicado: (2018)

mTOR Links Environmental Signals to T Cell Fate Decisions
por: Chapman, Nicole M., et al.
Publicado: (2015)

Self-assembled monolayers of alendronate on Ti6Al4V alloy surfaces enhance osteogenesis in mesenchymal stem cells
por: Rojo, Luis, et al.
Publicado: (2016)

STAT3 and mTOR: co-operating to drive HIF and angiogenesis
por: Dodd, Kayleigh M., et al.
Publicado: (2015)

HIF is not essential for suppression of experimental tumor growth by mTOR inhibition
por: Knaup, Karl X., et al.
Publicado: (2017)

Resveratrol improves palmitic acid‑induced insulin resistance via the DDIT4/mTOR pathway in C2C12 cells
por: Pan, Xinyan, et al.
Publicado: (2023)

ARHGAP4 mediates the Warburg effect in pancreatic cancer through the mTOR and HIF-1α signaling pathways
por: Shen, Yehua, et al.
Publicado: (2019)

The Fate of the Tumor in the Hands of Microenvironment: Role of TAMs and mTOR Pathway
por: Soave, Danilo Figueiredo, et al.
Publicado: (2016)

Revisiting mTOR and Epithelial–Mesenchymal Transition
por: Herrerias, Mariana M., et al.
Publicado: (2020)

HIF-1α increases the osteogenic capacity of ADSCs by coupling angiogenesis and osteogenesis via the HIF-1α/VEGF/AKT/mTOR signaling pathway
por: Song, Shuang, et al.
Publicado: (2023)

α-Enolase Lies Downstream of mTOR/HIF1α and Promotes Thyroid Carcinoma Progression by Regulating CST1
por: Liu, Yang, et al.
Publicado: (2021)

Inhibition of HIF1A-AS1 promoted starvation-induced hepatocellular carcinoma cell apoptosis by reducing HIF-1α/mTOR-mediated autophagy
por: Hong, Fenfen, et al.
Publicado: (2020)

HIF-mediated Suppression of DEPTOR Confers Resistance to mTOR Kinase Inhibition in Renal Cancer
por: Doan, Hong, et al.
Publicado: (2019)

Characterization of the transcriptional and metabolic responses of pediatric high grade gliomas to mTOR-HIF-1α axis inhibition
por: Nguyen, Aurélia, et al.
Publicado: (2017)

HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway
por: Xu, Wen-Ning, et al.
Publicado: (2020)

Canagliflozin attenuates lipotoxicity in cardiomyocytes and protects diabetic mouse hearts by inhibiting the mTOR/HIF-1α pathway
por: Sun, Pengbo, et al.
Publicado: (2021)

Metformin inhibits epithelial-mesenchymal transition of oral squamous cell carcinoma via the mTOR/HIF-1α/PKM2/STAT3 pathway
por: Yin, Weihuang, et al.
Publicado: (2021)

ATP Triggers Human Th9 Cell Differentiation via Nitric Oxide-Mediated mTOR-HIF1α Pathway
por: Roy, Suyasha, et al.
Publicado: (2019)

mTOR and ROS regulation by anethole on adipogenic differentiation in human mesenchymal stem cells
por: Rhee, Yun-Hee, et al.
Publicado: (2018)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

Mammalian Target of Rapamycin (mTOR) Signaling at the Crossroad of Muscle Fiber Fate in Sarcopenia
por: Sirago, Giuseppe, et al.
Publicado: (2022)

Combined PI3Kα-mTOR Targeting of Glioma Stem Cells
por: Eckerdt, Frank D., et al.
Publicado: (2020)

Myelination and mTOR
por: Figlia, Gianluca, et al.
Publicado: (2017)

Matrix IGF-1 regulates bone mass by activation of mTOR in mesenchymal stem cells
por: Xian, Lingling, et al.
Publicado: (2012)

High glucose induces the aging of mesenchymal stem cells via Akt/mTOR signaling
por: Zhang, Dayong, et al.
Publicado: (2017)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
por: Zou, Zhilin, et al.
Publicado: (2020)

Periosteum-derived mesenchymal stem cell alleviates renal fibrosis through mTOR-mediated Treg differentiation
por: Luo, Yongsheng, et al.
Publicado: (2023)

T memory stem cell formation: Caveat mTOR
por: Fowler, Daniel H., et al.
Publicado: (2016)

Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling
por: DU, YUEFENG, et al.
Publicado: (2015)

GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation
por: Carlessi, Rodrigo, et al.
Publicado: (2017)

Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway
por: Yan, Xianke, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bqke72c8e2c8v74f1dh3mmojct