Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism

Arsenic is a well-documented human carcinogen. The present study explored the role of the onco-miR, miR-21 and its target protein, programmed cell death 4 (PDCD4) in arsenic induced malignant cell transformation and tumorigenesis. Our results showed that treatment of human bronchial epithelial (BEAS...

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Detalles Bibliográficos
Autores principales: Pratheeshkumar, Poyil, Son, Young-Ok, Divya, Sasidharan Padmaja, Wang, Lei, Zhang, Zhuo, Shi, Xianglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120334/
https://www.ncbi.nlm.nih.gov/pubmed/27876813
http://dx.doi.org/10.1038/srep37227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120334/
https://www.ncbi.nlm.nih.gov/pubmed/27876813
http://dx.doi.org/10.1038/srep37227

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