The N-terminal loop of IRAK-4 death domain regulates ordered assembly of the Myddosome signalling scaffold

Activation of Toll-like receptors induces dimerization and the recruitment of the death domain (DD) adaptor protein MyD88 into an oligomeric post receptor complex termed the Myddosome. The Myddosome is a hub for inflammatory and oncogenic signaling and has a hierarchical arrangement with 6–8 MyD88 m...

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Detalles Bibliográficos
Autores principales: Dossang, Anthony C. G., Motshwene, Precious G., Yang, Yang, Symmons, Martyn F., Bryant, Clare E., Borman, Satty, George, Julie, Weber, Alexander N. R., Gay, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120336/
https://www.ncbi.nlm.nih.gov/pubmed/27876844
http://dx.doi.org/10.1038/srep37267

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