Cargando…

A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion

The counterregulatory response to hypoglycemia, which restores normal blood glucose levels to ensure sufficient provision of glucose to the brain, is critical for survival. To discover underlying brain regulatory systems, we performed a genetic screen in recombinant inbred mice for quantitative trai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Picard, Alexandre, Soyer, Josselin, Berney, Xavier, Tarussio, David, Quenneville, Simon, Jan, Maxime, Grouzmann, Eric, Burdet, Frédéric, Ibberson, Mark, Thorens, Bernard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120348/ https://www.ncbi.nlm.nih.gov/pubmed/27829151 http://dx.doi.org/10.1016/j.celrep.2016.10.041

Ejemplares similares

Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis
por: Picard, Alexandre, et al.
Publicado: (2021)

Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion
por: Picard, Alexandre, et al.
Publicado: (2022)

Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion
por: Strembitska, Anastasiya, et al.
Publicado: (2022)

α-cell glucokinase suppresses glucose-regulated glucagon secretion
por: Basco, Davide, et al.
Publicado: (2018)

Klf6 protects β-cells against insulin resistance-induced dedifferentiation
por: Dumayne, Christopher, et al.
Publicado: (2020)

Neuronal regulation of glucagon secretion and gluconeogenesis
por: Thorens, Bernard
Publicado: (2022)

Tmem117 in AVP neurons regulates the counterregulatory response to hypoglycemia
por: Gaspari, Sevasti, et al.
Publicado: (2023)

A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion
por: Berdous, Dassine, et al.
Publicado: (2020)

Glucose responsive neurons of the paraventricular thalamus control sucrose-seeking behavior
por: Labouèbe, Gwenaël, et al.
Publicado: (2016)

Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine
por: Thorens, Bernard, et al.
Publicado: (2019)

Plac8 is required for White Adipocyte Differentiation in vitro and Cell Number Control in vivo
por: Jimenez-Preitner, Maria, et al.
Publicado: (2012)

Hypothalamic Glucagon Receptors Regulate Feeding in Mice
por: Cunningham, Stephen E, et al.
Publicado: (2021)

Glucagon Stimulates Hepatic FGF21 Secretion through a PKA- and EPAC-Dependent Posttranscriptional Mechanism
por: Cyphert, Holly A., et al.
Publicado: (2014)

Glucokinase neurons of the paraventricular nucleus of the thalamus sense glucose and decrease food consumption
por: Kessler, Sébastien, et al.
Publicado: (2021)

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse
por: Gaspari, Sevasti, et al.
Publicado: (2022)

Different Transcriptional Control of Metabolism and Extracellular Matrix in Visceral and Subcutaneous Fat of Obese and Rimonabant Treated Mice
por: Poussin, Carine, et al.
Publicado: (2008)

Ins1(Cre) knock-in mice for beta cell-specific gene recombination
por: Thorens, Bernard, et al.
Publicado: (2014)

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis
por: Perry, Rachel J., et al.
Publicado: (2015)

Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion
por: Cruciani-Guglielmacci, Céline, et al.
Publicado: (2017)

Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation
por: Quenneville, Simon, et al.
Publicado: (2020)

Direct and indirect roles of Fgf3 and Fgf10 in innervation and vascularisation of the vertebrate hypothalamic neurohypophysis
por: Liu, Fang, et al.
Publicado: (2013)

Silencing of hypothalamic FGF11 prevents diet-induced obesity
por: Cho, Jae Hyun, et al.
Publicado: (2022)

Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans
por: Hansen, Jakob Schiøler, et al.
Publicado: (2015)

Glucagon secretion and signaling in the development of diabetes
por: Gaisano, Herbert Y., et al.
Publicado: (2012)

Regulating Glucagon Secretion: Somatostatin in the Spotlight
por: Rutter, Guy A.
Publicado: (2009)

Mechanisms of the Regulation and Dysregulation of Glucagon Secretion
por: Onyango, Arnold N.
Publicado: (2020)

EphrinB1 modulates glutamatergic inputs into POMC-expressing progenitors and controls glucose homeostasis
por: Gervais, Manon, et al.
Publicado: (2020)

Bariatric Surgery Induces a Differential Effect on Plasma Aldosterone in Comparison to Dietary Advice Alone
por: Berney, Maxime, et al.
Publicado: (2021)

Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21
por: Pena-Leon, Veronica, et al.
Publicado: (2022)

Model for Glucagon Secretion by Pancreatic α-Cells
por: González-Vélez, Virginia, et al.
Publicado: (2012)

Insulin Reciprocally Regulates Glucagon Secretion in Humans
por: Cooperberg, Benjamin A., et al.
Publicado: (2010)

Glucagon secretion from pancreatic α-cells
por: Briant, Linford, et al.
Publicado: (2016)

α-cell electrophysiology and the regulation of glucagon secretion
por: Gao, Rui, et al.
Publicado: (2023)

Glucagon Secreting Cells Responds to Insulin Secretion In vitro Using Immunocytochemistry
por: Aswar, MK, et al.
Publicado: (2010)

Glucagon-Like Peptide-1 Protects β-Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop
por: Cornu, Marion, et al.
Publicado: (2009)

Increased biogenesis of glucagon-containing secretory granules and glucagon secretion in BIG3-knockout mice
por: Li, Hongyu, et al.
Publicado: (2015)

Oxidative Phosphorylation Flexibility in the Liver of Mice Resistant to High-Fat Diet–Induced Hepatic Steatosis
por: Poussin, Carinne, et al.
Publicado: (2011)

Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice
por: Thorel, Fabrizio, et al.
Publicado: (2011)

Role of hypothalamic MAPK/ERK signaling and central action of FGF1 in diabetes remission
por: Brown, Jenny M., et al.
Publicado: (2021)

Hypothalamic CaMKKβ mediates glucagon anorectic effect and its diet-induced resistance
por: Quiñones, Mar, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_27gmt2q981pd2crds5aplt4edo