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Liposomal delivery systems for intestinal lymphatic drug transport

Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in the liver via the lymphatic route, which increases oral bioavailability. Various lipid-based nanoparticles have been used to deliver hydrophobic drugs to the lymphatic pathway. This revie...

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Autores principales: Ahn, Hyeji, Park, Ji-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120490/
https://www.ncbi.nlm.nih.gov/pubmed/27895934
http://dx.doi.org/10.1186/s40824-016-0083-1
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author Ahn, Hyeji
Park, Ji-Ho
author_facet Ahn, Hyeji
Park, Ji-Ho
author_sort Ahn, Hyeji
collection PubMed
description Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in the liver via the lymphatic route, which increases oral bioavailability. Various lipid-based nanoparticles have been used to deliver hydrophobic drugs to the lymphatic pathway. This review focuses on the liposomal delivery systems used for intestinal lymphatic drug transport. Liposomal formulations have attracted particular attention because they can stimulate the production of chylomicrons and the incorporated drugs readily associate with enterocyte-derived chylomicrons, enhancing lymphatic drug transport. We believe that a full understanding of their contribution to intestinal drug translocation will lead to effective oral delivery with liposomal formulations.
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spelling pubmed-51204902016-11-28 Liposomal delivery systems for intestinal lymphatic drug transport Ahn, Hyeji Park, Ji-Ho Biomater Res Review Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in the liver via the lymphatic route, which increases oral bioavailability. Various lipid-based nanoparticles have been used to deliver hydrophobic drugs to the lymphatic pathway. This review focuses on the liposomal delivery systems used for intestinal lymphatic drug transport. Liposomal formulations have attracted particular attention because they can stimulate the production of chylomicrons and the incorporated drugs readily associate with enterocyte-derived chylomicrons, enhancing lymphatic drug transport. We believe that a full understanding of their contribution to intestinal drug translocation will lead to effective oral delivery with liposomal formulations. BioMed Central 2016-11-23 /pmc/articles/PMC5120490/ /pubmed/27895934 http://dx.doi.org/10.1186/s40824-016-0083-1 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Ahn, Hyeji
Park, Ji-Ho
Liposomal delivery systems for intestinal lymphatic drug transport
title Liposomal delivery systems for intestinal lymphatic drug transport
title_full Liposomal delivery systems for intestinal lymphatic drug transport
title_fullStr Liposomal delivery systems for intestinal lymphatic drug transport
title_full_unstemmed Liposomal delivery systems for intestinal lymphatic drug transport
title_short Liposomal delivery systems for intestinal lymphatic drug transport
title_sort liposomal delivery systems for intestinal lymphatic drug transport
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120490/
https://www.ncbi.nlm.nih.gov/pubmed/27895934
http://dx.doi.org/10.1186/s40824-016-0083-1
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