High-specificity bioinformatics framework for epigenomic profiling of discordant twins reveals specific and shared markers for ACPA and ACPA-positive rheumatoid arthritis

BACKGROUND: Twin studies are powerful models to elucidate epigenetic modifications resulting from gene–environment interactions. Yet, commonly a limited number of clinical twin samples are available, leading to an underpowered situation afflicted with false positives and hampered by low sensitivity....

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Detalles Bibliográficos
Autores principales: Gomez-Cabrero, David, Almgren, Malin, Sjöholm, Louise K., Hensvold, Aase H., Ringh, Mikael V., Tryggvadottir, Rakel, Kere, Juha, Scheynius, Annika, Acevedo, Nathalie, Reinius, Lovisa, Taub, Margaret A., Montano, Carolina, Aryee, Martin J., Feinberg, Jason I., Feinberg, Andrew P., Tegnér, Jesper, Klareskog, Lars, Catrina, Anca I., Ekström, Tomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120506/
https://www.ncbi.nlm.nih.gov/pubmed/27876072
http://dx.doi.org/10.1186/s13073-016-0374-0

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