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Prognosis estimation under the light of metabolic tumor parameters on initial FDG-PET/CT in patients with primary extranodal lymphoma

BACKGROUND: Non-Hodgkin’s lymphomas arising from the tissues other than primary lymphatic organs are named primary extranodal lymphoma. Most of the studies evaluated metabolic tumor parameters in different organs and histopathologic variants of this disease generally for treatment response. We aimed...

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Autores principales: Okuyucu, Kursat, Ozaydın, Sukru, Alagoz, Engin, Ozgur, Gokhan, Ince, Semra, Oysul, Fahrettin Guven, Ozmen, Ozlem, Tuncel, Murat, Ozturk, Mustafa, Arslan, Nuri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120580/
https://www.ncbi.nlm.nih.gov/pubmed/27904443
http://dx.doi.org/10.1515/raon-2016-0045
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author Okuyucu, Kursat
Ozaydın, Sukru
Alagoz, Engin
Ozgur, Gokhan
Ince, Semra
Oysul, Fahrettin Guven
Ozmen, Ozlem
Tuncel, Murat
Ozturk, Mustafa
Arslan, Nuri
author_facet Okuyucu, Kursat
Ozaydın, Sukru
Alagoz, Engin
Ozgur, Gokhan
Ince, Semra
Oysul, Fahrettin Guven
Ozmen, Ozlem
Tuncel, Murat
Ozturk, Mustafa
Arslan, Nuri
author_sort Okuyucu, Kursat
collection PubMed
description BACKGROUND: Non-Hodgkin’s lymphomas arising from the tissues other than primary lymphatic organs are named primary extranodal lymphoma. Most of the studies evaluated metabolic tumor parameters in different organs and histopathologic variants of this disease generally for treatment response. We aimed to evaluate the prognostic value of metabolic tumor parameters derived from initial FDG-PET/CT in patients with a medley of primary extranodal lymphoma in this study. PATIENTS AND METHODS: There were 67 patients with primary extranodal lymphoma for whom FDG-PET/CT was requested for primary staging. Quantitative PET/CT parameters: maximum standardized uptake value (SUVmax), average standardized uptake value (SUVmean), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were used to estimate disease-free survival and overall survival. RESULTS: SUVmean, MTV and TLG were found statistically significant after multivariate analysis. SUVmean remained significant after ROC curve analysis. Sensitivity and specificity were calculated as 88% and 64%, respectively, when the cut-off value of SUVmean was chosen as 5.15. After the investigation of primary presentation sites and histo-pathological variants according to recurrence, there is no difference amongst the variants. Primary site of extranodal lymphomas however, is statistically important (p = 0.014). Testis and central nervous system lymphomas have higher recurrence rate (62.5%, 73%, respectively). CONCLUSIONS: High SUVmean, MTV and TLG values obtained from primary staging FDG-PET/CT are potential risk factors for both disease-free survival and overall survival in primary extranodal lymphoma. SUVmean is the most significant one amongst them for estimating recurrence/metastasis.
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spelling pubmed-51205802016-12-01 Prognosis estimation under the light of metabolic tumor parameters on initial FDG-PET/CT in patients with primary extranodal lymphoma Okuyucu, Kursat Ozaydın, Sukru Alagoz, Engin Ozgur, Gokhan Ince, Semra Oysul, Fahrettin Guven Ozmen, Ozlem Tuncel, Murat Ozturk, Mustafa Arslan, Nuri Radiol Oncol Research Article BACKGROUND: Non-Hodgkin’s lymphomas arising from the tissues other than primary lymphatic organs are named primary extranodal lymphoma. Most of the studies evaluated metabolic tumor parameters in different organs and histopathologic variants of this disease generally for treatment response. We aimed to evaluate the prognostic value of metabolic tumor parameters derived from initial FDG-PET/CT in patients with a medley of primary extranodal lymphoma in this study. PATIENTS AND METHODS: There were 67 patients with primary extranodal lymphoma for whom FDG-PET/CT was requested for primary staging. Quantitative PET/CT parameters: maximum standardized uptake value (SUVmax), average standardized uptake value (SUVmean), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were used to estimate disease-free survival and overall survival. RESULTS: SUVmean, MTV and TLG were found statistically significant after multivariate analysis. SUVmean remained significant after ROC curve analysis. Sensitivity and specificity were calculated as 88% and 64%, respectively, when the cut-off value of SUVmean was chosen as 5.15. After the investigation of primary presentation sites and histo-pathological variants according to recurrence, there is no difference amongst the variants. Primary site of extranodal lymphomas however, is statistically important (p = 0.014). Testis and central nervous system lymphomas have higher recurrence rate (62.5%, 73%, respectively). CONCLUSIONS: High SUVmean, MTV and TLG values obtained from primary staging FDG-PET/CT are potential risk factors for both disease-free survival and overall survival in primary extranodal lymphoma. SUVmean is the most significant one amongst them for estimating recurrence/metastasis. De Gruyter 2016-09-08 /pmc/articles/PMC5120580/ /pubmed/27904443 http://dx.doi.org/10.1515/raon-2016-0045 Text en © 2016 Radiol Oncol
spellingShingle Research Article
Okuyucu, Kursat
Ozaydın, Sukru
Alagoz, Engin
Ozgur, Gokhan
Ince, Semra
Oysul, Fahrettin Guven
Ozmen, Ozlem
Tuncel, Murat
Ozturk, Mustafa
Arslan, Nuri
Prognosis estimation under the light of metabolic tumor parameters on initial FDG-PET/CT in patients with primary extranodal lymphoma
title Prognosis estimation under the light of metabolic tumor parameters on initial FDG-PET/CT in patients with primary extranodal lymphoma
title_full Prognosis estimation under the light of metabolic tumor parameters on initial FDG-PET/CT in patients with primary extranodal lymphoma
title_fullStr Prognosis estimation under the light of metabolic tumor parameters on initial FDG-PET/CT in patients with primary extranodal lymphoma
title_full_unstemmed Prognosis estimation under the light of metabolic tumor parameters on initial FDG-PET/CT in patients with primary extranodal lymphoma
title_short Prognosis estimation under the light of metabolic tumor parameters on initial FDG-PET/CT in patients with primary extranodal lymphoma
title_sort prognosis estimation under the light of metabolic tumor parameters on initial fdg-pet/ct in patients with primary extranodal lymphoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120580/
https://www.ncbi.nlm.nih.gov/pubmed/27904443
http://dx.doi.org/10.1515/raon-2016-0045
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