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Disruption of PCNA-lamins A/C interactions by prelamin A induces DNA replication fork stalling

The accumulation of prelamin A is linked to disruption of cellular homeostasis, tissue degeneration and aging. Its expression is implicated in compromised genome stability and increased levels of DNA damage, but to date there is no complete explanation for how prelamin A exerts its toxic effects. As...

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Detalles Bibliográficos
Autores principales:	Cobb, Andrew M., Murray, Thomas V., Warren, Derek T., Liu, Yiwen, Shanahan, Catherine M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120601/ https://www.ncbi.nlm.nih.gov/pubmed/27676213 http://dx.doi.org/10.1080/19491034.2016.1239685

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